Rose Bengal Promoted Catalytic Amyloid-β Oxygenation by Sonoactivation

Wataru Atsumi; Keiichi Kawabata; Mina Yamane; Miku Oi; Harunobu Mitsunuma; Youhei Sohma; Yukiko Hori; Taisuke Tomita; Motomu Kanai

doi:10.1055/a-2182-7614

Synlett, Table of Contents

Synlett 2024; 35(08): 920-924
DOI: 10.1055/a-2182-7614

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Special Issue dedicated to Keith Fagnou

Rose Bengal Promoted Catalytic Amyloid-β Oxygenation by Sonoactivation

Wataru Atsumi

^aLaboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

,

Keiichi Kawabata

^aLaboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

,

Mina Yamane

^aLaboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

,

Miku Oi

^aLaboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

,

Harunobu Mitsunuma

^aLaboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

^bJST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan

,

Youhei Sohma∗

^cDepartment of Medicinal Chemistry, School of Pharmaceutical Sciences, Wakayama Medical University, 25-1 Shichibacho, Wakayama, 640-8156, Japan

,

Yukiko Hori∗

^dLaboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

,

Taisuke Tomita∗

^dLaboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

,

Motomu Kanai ∗

^aLaboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

› Author Affiliations

Abstract

All articles of this category

Dedicated to the memory of Professor Keith Fagnou

Abstract

Catalytic photooxygenation of amyloid-β is a leading therapeutic strategy for the treatment of Alzheimer disease; however, the limited tissue permeability of light hampers its clinical application. We here report an alternative catalytic sonooxygenation strategy to circumvent this problem. Amyloid-β aggregates were oxygenated by using rose bengal as a sonosensitizer under ultrasound irradiation. Structure–activity relationships revealed that xanthene-derived catalysts containing halogen atoms furnished a superior amyloid oxygenation activity.

Key words

Alzheimer disease - amyloid-β - amyloid oxygenation - ultrasound - sonodynamic therapy - sonosensitization

Full Text

References

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