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Synlett 2024; 35(01): 135-139
DOI: 10.1055/a-2201-3612
DOI: 10.1055/a-2201-3612
cluster
Functional Dyes
Purine-Based AIEgens with Different Morpholine Substitution Sites and Their Application in Lipophagy Imaging
This work was financially supported by the National Natural Science Foundation of China (No. 22077088 and 22207079) and Foundation from the Science and Technology Department of Sichuan Province (2021YFH0132).
Abstract
Lysosomes are an important organelle involved in many physiological processes. However, enhancing the accurate localization of lysosomes by chemical modification is still a problem. Herein, the purine-based AIEgens with different morpholine substitution sites were constructed. The effects of modification sites on the absorption, fluorescence, pH, viscosity and bioimaging properties of the probes were systematically studied. The morpholine modification at the phenyl site could effectively enhance the fluorescence behavior and the lysosome specificity. The morpholine-modified AIEgens could achieve the further lysosome imaging during the lipophagy process. This basic study might do favor to design more probes for further lysosome function studies.
Key words
purine - aggregation-induced emission - lipophagy - morpholine - lysosome-targeting - fluorescent probeSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2201-3612.
- Supporting Information
Publication History
Received: 16 June 2023
Accepted after revision: 30 October 2023
Accepted Manuscript online:
30 October 2023
Article published online:
15 November 2023
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