anti-Selective Synthesis of Substituted β-Homoprolines by Rhodium Alkyl Nitrene C–H Insertion

Abstract

A range of β-homoprolines was prepared with high anti-selectivity. An intramolecular C–H insertion reaction involving a rhodium alkyl nitrene is a key step in the ring construction. The carboxylic acid in the products can serve as a springboard for further downstream transformations.

Key words

rhodium catalysis - β-amino acids - nitrenes - N-heterocycles - C–H functionalization - homoprolines

• References and Notes

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