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CC BY-NC-ND 4.0 · Endosc Int Open 2023; 11(12): E1116-E1122
DOI: 10.1055/a-2206-4486
Original article

Colorectal serrated lesions and polyps in the Danish population: A large nationwide register-based cohort study

Mille Andrea 
1   Department of Pathology, Copenhagen University Hospital – Herlev and Gentofte, Herlev, Denmark
,
Rikke Karlin Jepsen
1   Department of Pathology, Copenhagen University Hospital – Herlev and Gentofte, Herlev, Denmark
,
Mads Falk Klein
2   Department of Surgery, Copenhagen University Hospital – Herlev and Gentofte, Herlev, Denmark
3   Department of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Kobenhavn, Denmark (Ringgold ID: RIN53139)
,
Ismail Gögenur
4   Center for Surgical Science, Department of Surgery, Zealand University Hospital Koge, Koge, Denmark (Ringgold ID: RIN524788)
3   Department of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Kobenhavn, Denmark (Ringgold ID: RIN53139)
,
Tine Plato Kuhlmann
1   Department of Pathology, Copenhagen University Hospital – Herlev and Gentofte, Herlev, Denmark
3   Department of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Kobenhavn, Denmark (Ringgold ID: RIN53139)
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Abstract

Background and study aims Colorectal serrated lesions and polyps (SPs) include hyperplastic polyps (HP), sessile serrated lesions-/+dysplasia (SSL/SSL-D), and traditional serrated adenomas (TSA). From 20% to 30% of colorectal cancers (CRC) develop from SP. We present incidence and baseline characteristics of SP in a Danish cohort.

Patients and methods We used The Danish Pathology Registry to include all SPs in the Danish population from January 1, 2000 to December 31, 2021. Based on the unique Danish personal identification number and SNOMED-codes, combined with the age and sex of patients, and date of procedure, we determined the incidence of the SP subtypes, anatomical location, and changes over time.

Results During the period from 2000 to 2021, a total of 292,761 SPs were removed from 163,840 patients: 51,649 SSLs, 5959 SSL-Ds, 224,860 HDs, and 10,293 TSAs. The median age of patients was 64.1 years (range 55.2–71.6) and 53.3% were male. We found a general increase in SPs from 3525 in 2000 to 25,853 in 2021 and a rise in the SSL proportion from 1.7% in 2006 to 38% in 2021. Half of all patients had more than one lesion at endoscopy with conventional adenomas being the most common. CRC was found along with SPs in 3.3% of procedures, while 1% to 2.5% of the patients developed metachronous CRC.

Conclusions We found an increasing number of SPs, especially SSLs. From 2019 to 2021 the number of SPs seem to stabilize, while the proportion of SSLs keeps rising. Synchronous lesions were common along all subtypes of SP.

Keywords

Colorectal cancer - CRC screening - GI Pathology - Epidemiology

Supporting information



Publication History

Received: 24 May 2023

Accepted after revision: 06 November 2023

Article published online:
12 December 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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