Download PDF
Klin Monbl Augenheilkd 2024; 241(02): 170-176
DOI: 10.1055/a-2239-0123
Übersicht

Internistische Erkrankungen und Zusammenhang mit dem primären Offenwinkelglaukom

Article in several languages: deutsch | English
Anna Maria Voigt
Augenklinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Deutschland
,
Stephanie Grabitz
Augenklinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Deutschland
,
Esther Maria Hoffmann
Augenklinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Deutschland
,
Alexander K. Schuster
Augenklinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Deutschland
› Author Affiliations
› Further Information
Also available at
    Permissions and Reprints

Zusammenfassung

Das primäre Offenwinkelglaukom (POWG) stellt eine neurodegenerative Erkrankung dar, in dessen Verlauf es zu einer glaukomatösen Optikusatrophie mit korrespondierenden Gesichtsfelddefekten kommt. In dieser Literaturübersicht werden Zusammenhänge zu internistischen Erkrankungen berichtet und die zugrunde liegende Pathophysiologie diskutiert. Hierbei wird die arterielle Hypertonie und Hypotonie, Diabetes mellitus, Dyslipidämien, obstruktive Schlafapnoe, chronischer Nierenerkrankung und Migräne diskutiert sowie Zusammenhänge mit der Einnahme von Medikamenten bei systemischen Erkrankungen näher betrachten.

Schlüsselwörter

Glaukom - Bluthochdruck - Hypotonie - Diabetes - Migräne


Publication History

Received: 26 October 2023

Accepted: 15 December 2023

Article published online:
27 February 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References/Literatur

  • 1 Tham YC, Cheng CY. Associations between chronic systemic diseases and primary open angle glaucoma: an epidemiological perspective. Clin Exp Ophthalmol 2017; 45: 24-32
    CrossrefPubMedSearch in Google Scholar
  • 2 Claessen H, Kvitkina T, Narres M. et al. Markedly decreasing incidence of cause-specific blindness in Saxony (Eastern Germany). Graefes Arch Clin Exp Ophthalmol 2021; 259: 1089-1101
    CrossrefPubMedSearch in Google Scholar
  • 3 Huber M, Kölzsch M, Stahlmann R. et al. Ophthalmic drugs as part of polypharmacy in nursing home residents with glaucoma. Drugs Aging 2013; 30: 31-38
    CrossrefPubMedSearch in Google Scholar
  • 4 [Anonymous] Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet 2021; 398: 957-980
    CrossrefPubMedSearch in Google Scholar
  • 5 Mitchell P, Lee AJ, Rochtchina E. et al. Open-angle glaucoma and systemic hypertension: the blue mountains eye study. J Glaucoma 2004; 13: 319-326
    CrossrefPubMedSearch in Google Scholar
  • 6 Dielemans I, Vingerling JR, Algra D. et al. Primary open-angle glaucoma, intraocular pressure, and systemic blood pressure in the general elderly population. The Rotterdam Study. Ophthalmology 1995; 102: 54-60
    CrossrefPubMedSearch in Google Scholar
  • 7 Sun J, Zhou X, Kang Y. et al. Prevalence and risk factors for primary open-angle glaucoma in a rural northeast China population: a population-based survey in Bin County, Harbin. Eye (Lond) 2012; 26: 283-291
    CrossrefPubMedSearch in Google Scholar
  • 8 Wang S, Xu L, Jonas JB. et al. Major eye diseases and risk factors associated with systemic hypertension in an adult Chinese population: the Beijing Eye Study. Ophthalmology 2009; 116: 2373-2380
    CrossrefPubMedSearch in Google Scholar
  • 9 Zhao D, Cho J, Kim MH. et al. The association of blood pressure and primary open-angle glaucoma: a meta-analysis. Am J Ophthalmol 2014; 158: 615-627.9
    CrossrefPubMedSearch in Google Scholar
  • 10 Xu L, Wang H, Wang Y. et al. Intraocular pressure correlated with arterial blood pressure: the Beijing eye study. Am J Ophthalmol 2007; 144: 461-462
    CrossrefPubMedSearch in Google Scholar
  • 11 Flammer J, Orgül S, Costa VP. et al. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res 2002; 21: 359-393
    CrossrefPubMedSearch in Google Scholar
  • 12 Van Eijgen J, Melgarejo JD, Van Laeken J. et al. The relevance of arterial blood pressure in the management of glaucoma progression: a systematic review. Am J Hypertens 2023;
    CrossrefPubMedSearch in Google Scholar
  • 13 Tielsch JM, Katz J, Sommer A. et al. Hypertension, perfusion pressure, and primary open-angle glaucoma. A population-based assessment. Arch Ophthalmol 1995; 113: 216-221
    CrossrefPubMedSearch in Google Scholar
  • 14 Hayreh SS. Role of nocturnal arterial hypotension in the development of ocular manifestations of systemic arterial hypertension. Curr Opin Ophthalmol 1999; 10: 474-482
    CrossrefPubMedSearch in Google Scholar
  • 15 Wong TY, Mitchell P. The eye in hypertension. Lancet 2007; 369: 425-435
    CrossrefPubMedSearch in Google Scholar
  • 16 Memarzadeh F, Ying-Lai M, Chung J. et al. Blood pressure, perfusion pressure, and open-angle glaucoma: the Los Angeles Latino Eye Study. Invest Ophthalmol Vis Sci 2010; 51: 2872-2877
    CrossrefPubMedSearch in Google Scholar
  • 17 Grunwald JE, Piltz J, Hariprasad SM. et al. Optic nerve blood flow in glaucoma: effect of systemic hypertension. Am J Ophthalmol 1999; 127: 516-522
    CrossrefPubMedSearch in Google Scholar
  • 18 Graham SL, Drance SM. Nocturnal hypotension: role in glaucoma progression. Surv Ophthalmol 1999; 43 (Suppl. 1) S10-S16
    CrossrefPubMedSearch in Google Scholar
  • 19 Middeke M. Hypertonie: Die Krux der RR-Variabilität. Dtsch Arztebl 2014; 111: 4-8
    PubMedSearch in Google Scholar
  • 20 Melgarejo JD, Eijgen JV, Wei D. et al. Effect of 24-h blood pressure dysregulations and reduced ocular perfusion pressure in open-angle glaucoma progression. J Hypertens 2023; 41: 1785-1792
    CrossrefPubMedSearch in Google Scholar
  • 21 Lin KY, Hsih WH, Lin YB. et al. Update in the epidemiology, risk factors, screening, and treatment of diabetic retinopathy. J Diabetes Investig 2021; 12: 1322-1325
    CrossrefPubMedSearch in Google Scholar
  • 22 Zhao D, Cho J, Kim MH. et al. Diabetes, fasting glucose, and the risk of glaucoma: a meta-analysis. Ophthalmology 2015; 122: 72-78
    CrossrefPubMedSearch in Google Scholar
  • 23 Li Y, Mitchell W, Elze T. et al. Association Between Diabetes, Diabetic Retinopathy, and Glaucoma. Curr Diab Rep 2021; 21: 38
    CrossrefPubMedSearch in Google Scholar
  • 24 Cohen E, Kramer M, Shochat T. et al. Relationship Between Serum Glucose Levels and Intraocular Pressure, a Population-based Cross-sectional Study. J Glaucoma 2017; 26: 652-656
    CrossrefPubMedSearch in Google Scholar
  • 25 Li Y, Mitchell W, Elze T. et al. Association Between Diabetes, Diabetic Retinopathy, and Glaucoma. Curr Diab Rep 2021; 21: 38
    CrossrefPubMedSearch in Google Scholar
  • 26 Wang Y, Fawzi AA, Varma R. et al. Pilot study of optical coherence tomography measurement of retinal blood flow in retinal and optic nerve diseases. Invest Ophthalmol Vis Sci 2011; 52: 840-845
    CrossrefPubMedSearch in Google Scholar
  • 27 Dimitrova G, Chihara E, Takahashi H. et al. Quantitative Retinal Optical Coherence Tomography Angiography in Patients With Diabetes Without Diabetic Retinopathy. Invest Ophthalmol Vis Sci 2017; 58: 190-196
    CrossrefPubMedSearch in Google Scholar
  • 28 Kannel WB, Castelli WP, Gordon T. Cholesterol in the prediction of atherosclerotic disease. New perspectives based on the Framingham study. Ann Intern Med 1979; 90: 85-91
    CrossrefPubMedSearch in Google Scholar
  • 29 Huang G, Wang J, Li L. et al. Meta-Analysis of Dyslipidemia and Blood Lipid Parameters on the Risk of Primary Open-Angle Glaucoma. Comput Math Methods Med 2022; 2022: 1122994
    CrossrefPubMedSearch in Google Scholar
  • 30 Nusinovici S, Li H, Thakur S. et al. High-Density Lipoprotein 3 Cholesterol and Primary Open-Angle Glaucoma: Metabolomics and Mendelian Randomization Analyses. Ophthalmology 2022; 129: 285-294
    CrossrefPubMedSearch in Google Scholar
  • 31 Zeleznik OA, Kang JH, Lasky-Su J. et al. Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank. Nat Commun 2023; 14: 2860
    CrossrefPubMedSearch in Google Scholar
  • 32 Madjedi KM, Stuart KV, Chua SYL. et al. The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts. Ophthalmology 2022; 129: 986-996
    CrossrefPubMedSearch in Google Scholar
  • 33 Pertl L, Mossböck G, Wedrich A. et al. Triglycerides and Open Angle Glaucoma – A Meta-analysis with meta-regression. Sci Rep 2017; 7: 7829
    CrossrefPubMedSearch in Google Scholar
  • 34 Jordan AS, McSharry DG, Malhotra A. Adult obstructive sleep apnoea. Lancet 2014; 383: 736-747
    CrossrefPubMedSearch in Google Scholar
  • 35 Chaitanya A, Pai VH, Mohapatra AK. et al. Glaucoma and its association with obstructive sleep apnea: A narrative review. Oman J Ophthalmol 2016; 9: 125-134
    CrossrefPubMedSearch in Google Scholar
  • 36 Shi Y, Liu P, Guan J. et al. Association between glaucoma and obstructive sleep apnea syndrome: a meta-analysis and systematic review. PLoS One 2015; 10: e0115625
    CrossrefPubMedSearch in Google Scholar
  • 37 Liu S, Lin Y, Liu X. Meta-Analysis of Association of Obstructive Sleep Apnea With Glaucoma. J Glaucoma 2016; 25: 1-7
    CrossrefPubMedSearch in Google Scholar
  • 38 Cheong AJY, Wang SKX, Woon CY. et al. Obstructive sleep apnoea and glaucoma: a systematic review and meta-analysis. Eye (Lond) 2023; 37: 3065-3083
    CrossrefPubMedSearch in Google Scholar
  • 39 Wu X, Liu H. Obstructive sleep apnea/hypopnea syndrome increases glaucoma risk: evidence from a meta-analysis. Int J Clin Exp Med 2015; 8: 297-303
    PubMedSearch in Google Scholar
  • 40 Girkin CA, McGwin jr. G, McNeal SF. et al. Is there an association between pre-existing sleep apnoea and the development of glaucoma?. Br J Ophthalmol 2006; 90: 679-681
    CrossrefPubMedSearch in Google Scholar
  • 41 Muniesa M, Sánchez-de-la-Torre M, Huerva V. et al. Floppy eyelid syndrome as an indicator of the presence of glaucoma in patients with obstructive sleep apnea. J Glaucoma 2014; 23: e81-e85
    CrossrefPubMedSearch in Google Scholar
  • 42 Fan YY, Su WW, Liu CH. et al. Correlation between structural progression in glaucoma and obstructive sleep apnea. Eye (Lond) 2019; 33: 1459-1465
    CrossrefPubMedSearch in Google Scholar
  • 43 Kiekens S, De Groot V, Coeckelbergh T. et al. Continuous positive airway pressure therapy is associated with an increase in intraocular pressure in obstructive sleep apnea. Invest Ophthalmol Vis Sci 2008; 49: 934-940
    CrossrefPubMedSearch in Google Scholar
  • 44 Ng FYC, Song H, Tan BKJ. et al. Bidirectional association between glaucoma and chronic kidney disease: A systematic review and meta-analysis. EClinicalMedicine 2022; 49: 101498
    CrossrefPubMedSearch in Google Scholar
  • 45 Cho HK, Han JC, Choi JA. et al. Association Between Chronic Renal Disease and the Risk of Glaucoma Development: A 12-year Nationwide Cohort Study. Invest Ophthalmol Vis Sci 2021; 62: 27
    CrossrefPubMedSearch in Google Scholar
  • 46 Tham YC, Tao Y, Zhang L. et al. Is kidney function associated with primary open-angle glaucoma? Findings from the Asian Eye Epidemiology Consortium. Br J Ophthalmol 2020; 104: 1298-1303
    CrossrefPubMedSearch in Google Scholar
  • 47 Tham YC, Lim SH, Gupta P. et al. Inter-relationship between ocular perfusion pressure, blood pressure, intraocular pressure profiles and primary open-angle glaucoma: the Singapore Epidemiology of Eye Diseases study. Br J Ophthalmol 2018; 102: 1402-1406
    CrossrefPubMedSearch in Google Scholar
  • 48 Holappa M, Vapaatalo H, Vaajanen A. Many Faces of Renin-angiotensin System – Focus on Eye. Open Ophthalmol J 2017; 11: 122-142
    CrossrefPubMedSearch in Google Scholar
  • 49 Izzotti A, Bagnis A, Saccà SC. The role of oxidative stress in glaucoma. Mutat Res 2006; 612: 105-114
    CrossrefPubMedSearch in Google Scholar
  • 50 Lv W, Booz GW, Fan F. et al. Oxidative Stress and Renal Fibrosis: Recent Insights for the Development of Novel Therapeutic Strategies. Front Physiol 2018; 9: 105
    CrossrefPubMedSearch in Google Scholar
  • 51 Nongpiur ME, Wong TY, Sabanayagam C. et al. Chronic kidney disease and intraocular pressure: the Singapore Malay Eye Study. Ophthalmology 2010; 117: 477-483
    CrossrefPubMedSearch in Google Scholar
  • 52 Hu J, Bui KM, Patel KH. et al. Effect of hemodialysis on intraocular pressure and ocular perfusion pressure. JAMA Ophthalmol 2013; 131: 1525-1531
    CrossrefPubMedSearch in Google Scholar
  • 53 Lee JY, Kim JM, Shim SH. et al. Association Between Optic Disc Hemorrhage and Renal Function in South Korea. J Glaucoma 2018; 27: 251-256
    CrossrefPubMedSearch in Google Scholar
  • 54 Wang YC, Ling XC, Tsai WH. et al. Risks of Topical Carbonic Anhydrase Inhibitors in Glaucoma Patients With Chronic Kidney Disease: A Nationwide Population-Based Study. Am J Ophthalmol 2023; 253: 49-55
    CrossrefPubMedSearch in Google Scholar
  • 55 Stewart WF, Wood C, Reed ML. et al. Cumulative lifetime migraine incidence in women and men. Cephalalgia 2008; 28: 1170-1178
    CrossrefPubMedSearch in Google Scholar
  • 56 Breslau N, Rasmussen BK. The impact of migraine: Epidemiology, risk factors, and co-morbidities. Neurology 2001; 56 (6 Suppl. 1): S4-S12
    CrossrefPubMedSearch in Google Scholar
  • 57 Bashir A, Lipton RB, Ashina S. et al. Migraine and structural changes in the brain: a systematic review and meta-analysis. Neurology 2013; 81: 1260-1268
    CrossrefPubMedSearch in Google Scholar
  • 58 Dalkara T, Nozari A, Moskowitz MA. Migraine aura pathophysiology: the role of blood vessels and microembolisation. Lancet Neurol 2010; 9: 309-317
    CrossrefPubMedSearch in Google Scholar
  • 59 Gramer G, Weber BH, Gramer E. Migraine and Vasospasm in Glaucoma: Age-Related Evaluation of 2027 Patients With Glaucoma or Ocular Hypertension. Invest Ophthalmol Vis Sci 2015; 56: 7999-8007
    CrossrefPubMedSearch in Google Scholar
  • 60 Noseda R, Burstein R. Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain. Pain 2013; 154 (Suppl. 1) S44-S53
    CrossrefPubMedSearch in Google Scholar
  • 61 Klein BE, Klein R, Meuer SM. et al. Migraine headache and its association with open-angle glaucoma: the Beaver Dam Eye Study. Invest Ophthalmol Vis Sci 1993; 34: 3024-3027
    PubMedSearch in Google Scholar
  • 62 Wang JJ, Mitchell P, Smith W. Is there an association between migraine headache and open-angle glaucoma? Findings from the Blue Mountains Eye Study. Ophthalmology 1997; 104: 1714-1719
    CrossrefPubMedSearch in Google Scholar
  • 63 Huang JY, Su CC, Wang TH. et al. Migraine and increased risk of developing open angle glaucoma: a population-based cohort study. BMC Ophthalmol 2019; 19: 50
    CrossrefPubMedSearch in Google Scholar
  • 64 Xu C, Li J, Li Z. et al. Migraine as a risk factor for primary open angle glaucoma: A systematic review and meta-analysis. Medicine (Baltimore) 2018; 97: e11377
    CrossrefPubMedSearch in Google Scholar
  • 65 Wu A, Khawaja AP, Pasquale LR. et al. A review of systemic medications that may modulate the risk of glaucoma. Eye (Lond) 2020; 34: 12-28
    CrossrefPubMedSearch in Google Scholar
  • 66 Zheng W, Dryja TP, Wei Z. et al. Systemic Medication Associations with Presumed Advanced or Uncontrolled Primary Open-Angle Glaucoma. Ophthalmology 2018; 125: 984-993
    CrossrefPubMedSearch in Google Scholar
  • 67 Wettrell K, Pandolfi M. Effect of oral administration of various beta-blocking agents on the intraocular pressure in healthy volunteers. Exp Eye Res 1975; 21: 451-456
    CrossrefPubMedSearch in Google Scholar
  • 68 Ho H, Shi Y, Chua J. et al. Association of Systemic Medication Use With Intraocular Pressure in a Multiethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study. JAMA Ophthalmol 2017; 135: 196-202
    CrossrefPubMedSearch in Google Scholar
  • 69 Kim J, Kennedy Neary MT, Aschard H. et al. Statin Use in Relation to Intraocular Pressure, Glaucoma, and Ocular Coherence Tomography Parameters in the UK Biobank. Invest Ophthalmol Vis Sci 2022; 63: 31
    CrossrefPubMedSearch in Google Scholar
  • 70 Vergroesen JE, Schuster AK, Stuart KV. et al. Association of Systemic Medication Use with Glaucoma and Intraocular Pressure: The European Eye Epidemiology Consortium. Ophthalmology 2023; 130: 893-906
    CrossrefPubMedSearch in Google Scholar
  • 71 Abernethy DR, Schwartz JB. Calcium-antagonist drugs. N Engl J Med 1999; 341: 1447-1457
    CrossrefPubMedSearch in Google Scholar
  • 72 Osborne NN, Casson RJ, Wood JP. et al. Retinal ischemia: mechanisms of damage and potential therapeutic strategies. Prog Retin Eye Res 2004; 23: 91-147
    CrossrefPubMedSearch in Google Scholar
  • 73 Araie M, Mayama C. Use of calcium channel blockers for glaucoma. Prog Retin Eye Res 2011; 30: 54-71
    CrossrefPubMedSearch in Google Scholar