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DOI: 10.1055/a-2243-4802
Ocular Manifestations in a Context of Primary Hyperparathyroidism: A Report of Two Cases
Augenmanifestationen im Zusammenhang mit primärem Hyperparathyreoidismus: Ein Bericht über zwei Fälle![](https://www.thieme-connect.de/media/klimo/202404/lookinside/thumbnails/10-1055-a-2243-4802_klm0383-1.jpg)
Background
Several endocrine pathologies are commonly associated with ophthalmic involvement, such as diabetes and Gravesʼ disease [1]. The parathyroid glands produce parathyroid hormone (PTH), which plays a key role in the regulation of calcium and phosphate levels in the blood. Dysfunction of these small endocrine glands can lead to various systemic manifestations [2]. However, there is limited clinical information regarding a possible association between ocular manifestations and parathyroid gland disorders [3], [4].
We report here two cases of eye-related conditions associated with a history of primary hyperparathyroidism.
Publication History
Received: 28 October 2023
Accepted: 03 January 2024
Article published online:
23 April 2024
© 2024. Thieme. All rights reserved.
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References
- 1 Chopra R, Chander A, Jacob JJ. The eye as a window to rare endocrine disorders. Indian J Endocrinol Metab 2012; 16: 331-338
- 2 Michels TC, Kelly KM. Parathyroid disorders. Am Fam Physician 2013; 88: 249-257
- 3 Golan A, Savir H, Bar-Meir S. et al. Band keratopathy due to hyperparathyroidism. Ophthalmologica 1975; 171: 119-122
- 4 Lee DK, Eiferman RA. Ocular calcifications in primary hyperparathyroidism. Arch Ophthalmol 2006; 124: 136-137
- 5 Wong S, Zakov ZN, Albert DM. Scleral and choroidal calcifications in a patient with pseudohypoparathyroidism. Br J Ophthalmol 1979; 63: 177-180
- 6 Battaglia Parodi M, Arrigo A, Pina A. et al. Choroidal neovascularization complicating sclerochoroidal calcifications. Am J Ophthalmol Case Rep 2021; 24: 101235
- 7 Thomson AC, Brown GT, Dolores-Rodriguez A. et al. A Case of Extensive Bilateral Idiopathic Sclerochoroidal Calcification and Review of Literature. Int Med Case Rep J 2021; 14: 749-755
- 8 Honavar SG, Shields CL, Demirci H. et al. Sclerochoroidal calcification: clinical manifestations and systemic associations. Arch Ophthalmol 2001; 119: 833-840
- 9 Shields CL, Hasanreisoglu M, Saktanasate J. et al. Sclerochoroidal calcification: clinical features, outcomes, and relationship with hypercalcemia and parathyroid adenoma in 179 eyes. Retina 2015; 35: 547-554
- 10 Marchini G, Tosi R, Parolini B. et al. Choroidal calcification in Bartter syndrome. Am J Ophthalmol 1998; 126: 727-729
- 11 Vezzoli G, Soldati L, Jansen A. et al. Choroidal calcifications in patients with Gitelmanʼs syndrome. Am J Kidney Dis 2000; 36: 855-858
- 12 Zarnegar A, Ong J, Matsyaraja T. et al. Pathomechanisms in central serous chorioretinopathy: A recent update. Int J Retina Vitreous 2023; 9: 3
- 13 Nathaniel Roybal C, Sledz E, Elshatory Y. et al. Dysfunctional autonomic regulation of the choroid in central serous chorioretinopathy. Retina 2018; 38: 1205-1210
- 14 Cardillo Piccolino F, Lupidi M, Cagini C. et al. Choroidal Vascular Reactivity in Central Serous Chorioretinopathy. Invest Ophthalmol Vis Sci 2018; 59: 3897-3905
- 15 Jain M, Mohan S, van Dijk EHC. Central serous chorioretinopathy: Pathophysiology, systemic associations, and a novel etiological classification. Taiwan J Ophthalmol 2022; 12: 381-393
- 16 Fisher SB, Perrier ND. Primary hyperparathyroidism and hypertension. Gland Surg 2020; 9: 142-149
- 17 Pepe J, Cipriani C, Sonato C. et al. Cardiovascular manifestations of primary hyperparathyroidism: a narrative review. Eur J Endocrinol 2017; 177: R297-R308
- 18 Sabbadin C, Donà G, Bordin L. et al. Transient hypercortisolism and symptomatic hyperthyroidism associated to primary hyperparathyroidism in an elderly patient: case report and literature review. BMC Endocr Disord 2015; 15: 4
- 19 van Rijssen TJ, van Dijk EHC, Yzer S. et al. Central serous chorioretinopathy: Towards an evidence-based treatment guideline. Prog Retin Eye Res 2019; 73: 100770