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Synlett 2024; 35(15): 1813-1816
DOI: 10.1055/a-2251-4145
DOI: 10.1055/a-2251-4145
letter
Synthesis and α-Functionalisation of Cyclic Imines
Financial support from the Maurice Wilkins Centre for Molecular Biodiscovery and the Royal Society Te Aparangi Marsdon Fund is gratefully acknowledged.
Abstract
α-Functionalisation of cyclic imines is explored. The cyclic imine substrates are synthesised from their respective halonitrile precursors using a nucleophilic addition/cyclisation sequence. Selective monohalogenation of the cyclic imines yields α-haloimines, which serve as a platform to obtain various α-hydroxyimine derivatives. In addition, an unusual tautomerisation and oxidation sequence is observed in the attempted preparation of α-hydroxyimines.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2251-4145.
- Supporting Information
Publikationsverlauf
Eingereicht: 16. November 2023
Angenommen nach Revision: 22. Januar 2024
Accepted Manuscript online:
22. Januar 2024
Artikel online veröffentlicht:
13. Februar 2024
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