Rofo 2024; 196(10): 1022-1028
DOI: 10.1055/a-2254-5490
Review

Stellenwert der kontrastmittelgestützten Sonografie in der Diagnostik des vesikoureteralen Refluxes

Article in several languages: English | deutsch
Patrick Conen
1   Department of Radiology, Ludwig Maximilians University Munich, München, Germany
2   Interdisciplinary Ultrasound-Center, Ludwig Maximilians University Munich, München, Germany
,
Janine Thiemann
1   Department of Radiology, Ludwig Maximilians University Munich, München, Germany
2   Interdisciplinary Ultrasound-Center, Ludwig Maximilians University Munich, München, Germany
,
Regina Stredele
3   Department of Urology, Ludwig Maximilians University Munich, München, Germany
,
Dirk Andre Clevert
1   Department of Radiology, Ludwig Maximilians University Munich, München, Germany
2   Interdisciplinary Ultrasound-Center, Ludwig Maximilians University Munich, München, Germany
› Author Affiliations

Zusammenfassung

Hintergrund Kontrastmittelgestützter Ultraschall der ableitenden Harnwege und der Harnblase (ceVUS) ist eine in der Praxis zunehmende alternative Untersuchungsmethode zur Miktionscysturethrografie (MCU/VCUG) bei dem Verdacht auf einen vesikoureterorenalen Reflux (VUR). In dieser Übersichtsarbeit soll der aktuelle Stellenwert der ceVUS in der Diagnosestellung dargestellt werden.

Methode Es erfolgte eine systematische Literaturrecherche mit den Stichwörtern „vesicureteral reflux“, „ceVUS“, „VCUG“ der Datenbanken MEDLINE und Cochrane Library sowie eine Aufarbeitung der aktuellen deutschen, europäischen und amerikanischen Leitlinien zu diesem Thema. Darüber hinaus wurden Handlungsempfehlungen für den klinischen Alltag erarbeitet.

Schlussfolgerung Die ceVUS ist eine schnell zu erlernende Untersuchung, die der VCUG in der Diagnostik des vesikoureterorenalen Refluxes gleichzusetzen ist und bei fehlender Strahlenbelastung bei Verfügbarkeit als Diagnostik der ersten Wahl eingesetzt werden sollte.

Kernaussagen

  • Die ceVUS ist genauso wie die VCUG die Diagnostik der ersten Wahl bei Verdacht auf einen vesikoureterorenalen Reflux und sollte bei fehlender Strahlenexposition bevorzugt eingesetzt werden.

  • Die ceVUS ist insbesondere im Vergleich zur alternativen VCUG eine schnell zu erlernende Untersuchungsmethode.

  • Mit der ceVUS können auch weitere Pathologien der ableitenden Harnwege diagnostiziert werden.

Zitierweise

  • Conen P, Thiemann J, Stredele R et al. Value of contrast-enhanced sonography in the diagnosis of vesicoureteral reflux. Fortschr Röntgenstr 2024; 196: 1022 – 1028



Publication History

Received: 07 July 2023

Accepted: 19 December 2023

Article published online:
26 February 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Fanos V, Cataldi L. Antibiotics or surgery for vesicoureteric reflux in children. Lancet 2004; 364: 1720-1722
  • 2 Greenbaum LA, Mesrobian HG. Vesicoureteral reflux. Pediatr Clin North Am 2006; 53: 413-427, vi
  • 3 Ramage IJ, Schuckett B, McLorie GA. et al. Primary vesicoureteric reflux diagnosed in the 1st month of life. Pediatr Nephrol 1999; 13: 716-717
  • 4 Gesellschaft für Pädiatrische Nephrologie e. V. S2k-Leitlinie Harnwegsinfektionen im Kindesalter – Diagnostik, Therapie und Prophylaxe, Version 1.0, 2021, verfügbar unter. https://register.awmf.org/de/leitlinien/detail/166-004 Zugriff am 08.09.2023
  • 5 Chand DH, Rhoades T, Poe SA. et al. Incidence and severity of vesicoureteral reflux in children related to age, gender, race and diagnosis. J Urol 2003; 170: 1548-1550
  • 6 Willemsen J, Nijman RJ. Vesicoureteral reflux and videourodynamic studies: results of a prospective study. Urology 2000; 55: 939-943
  • 7 Hoberman A, Charron M, Hickey RW. et al. Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med 2003; 348: 195-202
  • 8 American Urological Association. Management and Screening of Primary Vesicoureteral Reflux in Children, 2017, verfügbar unter. https://www.auanet.org/guidelines-and-quality/guidelines/vesicoureteral-reflux-guideline Zugriff am 08.09.2023
  • 9 Tekgül S, Riedmiller H, Hoebeke P. et al. EAU Guidelines on Vesicoureteral Reflux in Children. Eur. Urol 2012; 62 (03) P534-P542
  • 10 Rothwell DL, Constable AR, Albrecht M. Radionuclide cystography in the investigation of vesicoureteric reflux in children. Lancet 1977; 1: 1072-1075
  • 11 Arapovic A, Punda A, Brdar D. et al. Types of Parenchymal Changes Diagnosed on DMSA Scans of Kidneys Affected by Different Grades of Vesicoureteral Reflux. Med Sci Monit 2021; 27: e929617
  • 12 Lebowitz RL, Olbing H, Parkkulainen KV. et al. International system of radiographic grading of vesicoureteric reflux. International Reflux Study in Children. Pediatr Radiol 1985; 15: 105-109
  • 13 Benya EC, Prendergast FM, Liu DB. et al. Assessment of distal ureteral and ureterovesical junction visualization on contrast-enhanced voiding urosonography. Pediatr Radiol 2021; 51: 1406-1411
  • 14 Thomsen HS, Rygaard H, Strandberg C. Micturating cystourethrography and vesicoureteral reflux. Eur J Radiol 1985; 5: 318-320
  • 15 Gudbjerg CE, Hansen LK, Hasner E. Micturition cysto-urethrography; automatic serial technique. Acta radiol 1958; 50: 310-315
  • 16 Bundesamt für Strahlenschutz. Bekanntmachung der aktualisierten diagnostischen Referenzwerte für diagnostische und interventionelle Röntgenanwendungen.
  • 17 Schneider K, Krüger-Stollfuss I, Ernst G. et al. Paediatric fluoroscopy—a survey of children’s hospitals in Europe. I. Staffing, frequency of fluoroscopic procedures and investigation technique. Pediatr Radiol 2001; 31 (04) 238-246
  • 18 Likartsis C, Printza N, Notopoulos A. Radionuclide techniques for the detection of vesicoureteral reflux and their clinical significance. Hell J Nucl Med 2020; 23 (02) 180-187
  • 19 Schneider K, Jablonski C, Wiessner M. et al. Screening for vesicoureteral reflux in children using real-time sonography. Pediatr Radiol 1984; 14 (06) 400-403
  • 20 Alzen G, Wildberger JE, Ferris EJ. et al. Sonographic detection of vesicoureteral reflux with air: a new method. Eur Radiol 1994; 4: 142-145
  • 21 Darge K. Voiding urosonography with ultrasound contrast agents for the diagnosis of vesicoureteric reflux in children. I. Procedure. Pediatr Radiol 2008; 38 (01) 40-53
  • 22 Darge K. Voiding urosonography with US contrast agents for the diagnosis of vesicoureteric reflux in children. II. Comparison with radiological examinations. Pediatr Radiol 2008; 38 (01) 54-63
  • 23 Robrecht J, Darge K. [In-vitro comparison of a 1st and a 2nd generation US contrast agent for reflux diagnosis]. Rofo Fortschr 2007; 179 (08) 818-825
  • 24 Darge K, Moeller RT, Trusen A. et al. Diagnosis of vesicoureteric reflux with low-dose contrast-enhanced harmonic ultrasound imaging. Pediatr Radiol 2005; 35 (01) 73-78
  • 25 Darge K, Troeger J, Duetting T. et al. Reflux in young patients: comparison of voiding US of the bladder and retrovesical space with echo enhancement versus voiding cystourethrography for diagnosis. Radiology 1999; 210 (01) 201-207
  • 26 Darge K, Troeger J. Vesicoureteral reflux grading in contrast-enhanced voiding urosonography. Eur J Radiol 2002; 43 (02) 122-128
  • 27 Mentzel HJ, Vogt S, John U. et al. Voiding urosonography with ultrasonography contrast medium in children. Pediatr Nephrol 2002; 17 (04) 272-276
  • 28 Marschner CA, Schwarze V, Stredele R. et al. Evaluation of the Diagnostic Value of Contrast-Enhanced Voiding Urosonography with Regard to the Further Therapy Regime and Patient Outcome-A Single-Center Experience in an Interdisciplinary Uroradiological Setting. Medicina (Kaunas) 2021; 57
  • 29 Ključevšek D, Battelino N, Tomažič M. et al. A comparison of echo-enhanced voiding urosonography with X-ray voiding cystourethrography in the first year of life. Acta Paediatr 2012; 101: e235-e239
  • 30 Roic AC, Milošević D, Turudić D. et al. An innovative diagnostic procedure in children: videourodynamics with contrast-enhanced voiding urosonography. J Ultrasound 2022;
  • 31 Velasquez M, Emerson MG, Diaz E. et al. The learning curve of contrast-enhanced “microbubble” voiding urosonography-validation study. J Pediatr Urol 2019; 15: 385.e381-385.e386
  • 32 Seelbach J, Krüger PC, Waginger M. et al. Safety and parents’ acceptance of ultrasound contrast agents in children and adolescents – contrast enhanced voiding urosonography and contrast enhanced ultrasound. Med Ultrason 2022; 24: 27-32
  • 33 Benya EC, Prendergast FM, Liu DB. et al. Assessment of distal ureteral and ureterovesical junction visualization on contrast-enhanced voiding urosonography. Pediatr Radiol 2021; 51 (08) 1406-1411
  • 34 Barnewolt CE, Acharya PT, Aguirre Pascual E. et al. Contrast-enhanced voiding urosonography part 2: urethral imaging. Pediatr Radiol 2021; 51 (12) 2368-2386
  • 35 Kim D, Hun Choi Y, Choi G. et al. Contrast-enhanced voiding urosonography for the diagnosis of vesicoureteral reflux and intrarenal reflux: a comparison of diagnostic performance with fluoroscopic voiding cystourethrography. Ultrasonography 2021; 40 (04) 530-537
  • 36 Klein EL, Wyers MR, Prendergast FM. et al. Prevalence of intrarenal reflux in pediatric patients on contrast-enhanced voiding urosonography. Pediatr Radiol 2023; 53 (03) 387-393
  • 37 Pfitzinger PL, Stredele RJF, Eismann L. et al. [Special diagnostics in pediatric urology-Ultrasound, VCUG, CT and MRI: Part 1: tips for the practice]. Urologie 2022; 61: 782-791
  • 38 Oh S, Ha JY, Cho YJ. Contrast-enhanced voiding ultrasonography to detect intrarenal reflux in children: comparison with 99mTc-DMSA renal scans. Ultrasonography 2022; 41 (03) 502-510
  • 39 Kljucevsek D, Pecanac O, Tomazic M. et al. Potential causes of insufficient bladder contrast opacification and premature microbubble destruction during contrast-enhanced voiding urosonography in children. J Clin Ultrasound 2019; 47 (01) 36-41
  • 40 Sinha R, Saha S, Maji B. et al. Antibiotics for performing voiding cystourethrogram: a randomised control trial. Arch Dis Chil 2018; 103 (03) 230-234
  • 41 Autore G, Bernardi L, Ghidini F. et al. Antibiotic Prophylaxis for the Prevention of Urinary Tract Infections in Children: Guideline and Recommendations from the Emilia-Romagna Pediatric Urinary Tract Infections (UTI-Ped-ER) Study Group. Antibiotics (Basel) 2023; 12 (06) 1040
  • 42 Chung YE, Kim KW. Contrast-enhanced ultrasonography: advance and current status in abdominal imaging. Ultrasonography 2015; 34: 3-18
  • 43 American College of Radiology Committee on Drugs and Contrast Media. ACR Manual on Contrast Media, Version 2023, verfügbar unter. https://www.acr.org/-/media/acr/files/clinical-resources/contrast_media.pdf Zugriff am 08.09.2023
  • 44 Ntoulia A, Anupindi SA, Back SJ. et al. Contrast-enhanced ultrasound: a comprehensive review of safety in children. Pediatr Radiol 2021; 51 (12) 2161-2180
  • 45 Darge K, Papadopoulou F, Ntoulia A. et al. Safety of contrast-enhanced ultrasound in children for non-cardiac applications: a review by the Society for Pediatric Radiology (SPR) and the International Contrast Ultrasound Society (ICUS). Pediatr Radiol 2013; 43 (09) 1063-1073
  • 46 Riccabona M, Avni FE, Blickman JG. Imaging recommendations in paediatric uroradiology: minutes of the ESPR workgroup session on urinary tract infection, fetal hydronephrosis, urinary tract ultrasonography and voiding cystourethrography, Barcelona, Spain, June 2007. Pediatr Radiol 2008; 38 (02) 138-145
  • 47 Fachinformation (Zusammenfassung der Merkmale des Arzneimittels) SonoVue. Verfügbar unter. https://www.bracco.com/sites/default/files/2023-05/fachinfo-sonovue.pdf Zugriff am: 08.09.2023