Abstract
Objective To characterize the relationship between gut microbiota and neonatal acute kidney injury biomarkers based on the gut-kidney axis.
Study Design The Pubmed database was primarily searched to include relevant literature on gut microbiota and neonatal acute kidney injury biomarkers, which was subsequently organized and analyzed and a manuscript was written.
Results Gut microbiota was associated with neonatal acute kidney injury biomarkers. These biomarkers included TIMP-2, IGFBP-7, VEGF, calbindin, GST, B2MG, ghrelin, and clusterin.
Conclusion The gut microbiota is strongly associated with neonatal acute kidney injury biomarkers, and controlling the gut microbiota may be a potential target for ameliorating neonatal acute kidney injury.
Key Points
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There is a bidirectional association between gut microbiota and AKI.
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Gut microbiota is closely associated with biomarkers of nAKI.
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Manipulation of gut microbiota may improve nAKI.
Keywords
gut microbiota - neonatal acute kidney injury - gut–kidney axis - biomarkers
