Gut Microbiota and Neonatal Acute Kidney Injury

Kun Yang; Hongxia He; Wenbin Dong

doi:10.1055/a-2259-0101

American Journal of Perinatology, Table of Contents

Am J Perinatol 2024; 41(14): 1887-1894
DOI: 10.1055/a-2259-0101

Review Article

Gut Microbiota and Neonatal Acute Kidney Injury

Authors

Kun Yang

¹Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China

²Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China

³Sichuan Clinical Research Center for Birth Defects, Luzhou, China
Hongxia He

¹Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China

²Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China

³Sichuan Clinical Research Center for Birth Defects, Luzhou, China
Wenbin Dong

¹Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China

²Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China

³Sichuan Clinical Research Center for Birth Defects, Luzhou, China

Abstract

Objective To characterize the relationship between gut microbiota and neonatal acute kidney injury biomarkers based on the gut-kidney axis.

Study Design The Pubmed database was primarily searched to include relevant literature on gut microbiota and neonatal acute kidney injury biomarkers, which was subsequently organized and analyzed and a manuscript was written.

Results Gut microbiota was associated with neonatal acute kidney injury biomarkers. These biomarkers included TIMP-2, IGFBP-7, VEGF, calbindin, GST, B2MG, ghrelin, and clusterin.

Conclusion The gut microbiota is strongly associated with neonatal acute kidney injury biomarkers, and controlling the gut microbiota may be a potential target for ameliorating neonatal acute kidney injury.

Key Points

There is a bidirectional association between gut microbiota and AKI.
Gut microbiota is closely associated with biomarkers of nAKI.
Manipulation of gut microbiota may improve nAKI.

Keywords

gut microbiota - neonatal acute kidney injury - gut–kidney axis - biomarkers

Full Text

References

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