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CC BY-NC-ND 4.0 · Endosc Int Open 2024; 12(03): E413-E418
DOI: 10.1055/a-2261-2711
Original article

Artificial intelligence for characterization of colorectal polyps: Prospective multicenter study

Glenn De Lange 
1   Faculty of Medicine, University of Geneva, Geneve, Switzerland (Ringgold ID: RIN27212)
,
Victor Prouvost
2   IMAD, Centre Hospitalier Universitaire de Nantes, Nantes, France (Ringgold ID: RIN26922)
,
Gabriel Rahmi
3   Hôpital Européen Georges Pompidou Hépato-gastro-entérologie et oncologie disgestive, Paris, France (Ringgold ID: RIN543031)
,
Geoffroy Vanbiervliet 
4   Pôle digestif, Centre Hospitalier Universitaire de Nice, Nice, France (Ringgold ID: RIN37045)
,
Catherine Le Berre
2   IMAD, Centre Hospitalier Universitaire de Nantes, Nantes, France (Ringgold ID: RIN26922)
,
Sahar Mack
5   Service de Gastroentérologie et d'hépatologie, Hôpitaux Universitaires Genève, Geneve, Switzerland (Ringgold ID: RIN27230)
,
Thibaud Koessler
6   Service d'oncologie, Hôpitaux Universitaires Genève, Geneve, Switzerland (Ringgold ID: RIN27230)
,
Emmanuel Coron
5   Service de Gastroentérologie et d'hépatologie, Hôpitaux Universitaires Genève, Geneve, Switzerland (Ringgold ID: RIN27230)
2   IMAD, Centre Hospitalier Universitaire de Nantes, Nantes, France (Ringgold ID: RIN26922)
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Abstract

Background and study aims Optical diagnosis poses challenges to implementation of "resect and discard" strategies. This study aimed to assess the feasibility and performance of a new commercially available system for colorectal polyps.

Patients and methods Nine expert endoscopists in three centers performed colonoscopies using artificial intelligence-equipped colonoscopes (CAD EYE, Fujifilm). Histology and predictions were compared, with hyperplastic polyps and sessile serrated lesions grouped for analysis.

Results Overall, 253 polyps in 119 patients were documented (n=152 adenomas, n=78 hyperplastic polyps, n=23 sessile serrated lesions). CAD EYE detected polyps before endoscopists in 81 of 253 cases (32%). The mean polyp size was 5.5 mm (SD 0.6 mm). Polyp morphology was Paris Ip (4 %), Is (28 %), IIa (60 %), and IIb (8 %). CAD EYE achieved a sensitivity of 80%, specificity of 83%, positive predictive value (PPV) of 96%, and negative predictive value (NPV) of 72%. Expert endoscopists had a sensitivity of 88%, specificity of 83%, PPV of 96%, and NPV of 72%. Diagnostic accuracy was similar between CAD EYE (81%) and endoscopists (86%). However, sensitivity was greater with endoscopists as compared with CAD EYE (P <0.05). CAD EYE classified sessile serrated lesions as hyperplasia in 22 of 23 cases, and endoscopists correctly classified 16 of 23 cases.

Conclusions The CAD EYE system shows promise for detecting and characterizing colorectal polyps. Larger studies are needed, however, to confirm these findings.

Keywords

Colorectal cancer - CRC screening - Endoscopy Lower GI Tract - Polyps / adenomas / ...


Publication History

Received: 28 August 2023

Accepted after revision: 01 February 2024

Accepted Manuscript online:
05 February 2024

Article published online:
18 March 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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