Synthesis, Inhaltsverzeichnis Synthesis 2024; 56(15): 2339-2346DOI: 10.1055/a-2284-9845 paper Photoredox-Catalyzed Oxidative C–H Alkylation of Glycine Derivatives with 4-Alkyl-1,4-dihydropyridines Madala Hari Babu‡ a College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea , Eunbin Jang‡ b College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea , Hyesu Jang b College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea , Sang Kyum Kim b College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea , Jaehoon Sim ∗ a College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea c Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea d Institute of Regulatory Innovation through Science, Kyung Hee University, Seoul 02447, Republic of Korea › Institutsangaben Artikel empfehlen Abstract Artikel einzeln kaufen Alle Artikel dieser Rubrik Abstract Oxidative α-C(sp3)–H alkylation of N-arylated glycine derivatives with 4-alkyldihydropyridine derivatives (alkyl-DHPs) as versatile alkyl radical precursors has been developed. Utilizing visible-light-driven photoredox catalysis and ammonium persulfate as an oxidizing agent, this methodology facilitates the site-selective alkylation of glycine derivatives, enabling the site-selective alkylation of peptides. The reaction exhibits broad substrate scope, including various alkyl radicals and acid-labile functional groups. This approach expands the synthetic toolbox in peptide chemistry, offering a mild and efficient method for the synthesis of modified peptides. Key words Key wordsunnatural amino acids - photocatalysis - 4-alkyl-1,4-dihydropyridines - persulfate - peptides Volltext Referenzen References 1a Gray BP, Brown KC. Chem. Rev. 2014; 114: 1020 1b Lau JL, Dunn MK. Bioorg. Med. Chem. 2018; 26: 2700 2a Zorzi A, Deyle K, Heinis C. Curr. Opin. Chem. Biol. 2017; 38: 24 2b Fosgerau K, Hoffmann T. Drug Discovery Today 2015; 20: 122 2c Henninot A, Collins JC, Nuss JM. J. Med. Chem. 2018; 61: 1382 3a Vinogradov AA, Yin Y, Suga H. J. Am. Chem. 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