A Facile Procedure for Halodecarboxylation of Hydroxyaromatic Carboxylic Acids

Abstract

An efficient approach is reported for the direct halodecarboxylation of hydroxyaromatic acids by using a readily available N-halosuccinimide (halo = Cl, Br) as the sole promoter in ethanol at room temperature without any other catalyst or additive. This environmentally friendly route tolerates a wide substrate scope with good to excellent yields under convenient conditions.

Key words

halogenation - decarboxylation - N-chlorosuccinimide - N-bromosuccinimide - hydroxyaromatic acids - trihalophenols

Publication History

Received: 03 January 2024

Accepted after revision: 25 March 2024

Accepted Manuscript online:
25 March 2024

Article published online:
23 April 2024

• References and Notes

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