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CC BY 4.0 · Synlett 2024; 35(19): 2174-2190
DOI: 10.1055/a-2331-6399
DOI: 10.1055/a-2331-6399
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Isotopic Labeling
Multicomponent Reactions: A Promising Approach to Isotope Labeling
This research has been supported (to AD) through the ERA Chair grant ACCELERATOR (101087318), the ERC Advanced grant AMADEUS (101098001), and the VIDEC grant (872195). This study was supported (AD) by the National Institute for Cancer Research—Programme EXCELES (ID Project No. LX22NPO5102), funded by the Cancer Research Czech Republic, and the Dutch Cancer Society (KWF Kankerbestrijding, KWF) grant (14712).
Abstract
Isotopic labeling is an attractive modality that has been widely used in many aspects of chemistry, the life sciences, and medical research; especially deuterated drugs and radioactive molecules have been used in the diagnosis and treatment of cancer and neurodegenerative diseases. The widespread application and rapid development of isotopically labeled molecules has led to an increased demand for new isotopic labeling chemical methods to synthesize highly specific molecules bearing defined nuclides. Multicomponent reactions (MCRs) are modular build-up approaches for the rapid generation of complex molecules often containing biologically relevant scaffold structures. There is great potential to use MCRs to construct isotopically labeled molecules because assembly speed and reaction diversity are key advantages of MCR. In this review, we provide an overview of the recent literature on this topic that can provide insight into the application of MCRs in the field of isotopic labeling.
Publication History
Received: 11 February 2024
Accepted after revision: 22 May 2024
Accepted Manuscript online:
22 May 2024
Article published online:
18 September 2024
© 2024. The Authors. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)
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