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DOI: 10.1055/a-2335-8290
Effect of chewing gum in bowel preparation for patients undergoing small bowel and colon capsule endoscopy: Systematic review with meta-analysis
Clinical Trial: Registration number (trial ID): CRD42022385214, Trial registry: PROSPERO, Type of Study: prospective randomized controlled trial
Abstract
Background and study aims Quality of bowel preparation and successful transit are critical factors for complete small bowel capsule endoscopy (SBCE) and colon capsule endoscopy (CCE). The aim of this systematic review with meta-analysis was to assess the impact of chewing gum as part of the bowel preparation regimen on the completion rate in both SBCE and CCE.
Methods A systematic literature search was conducted in PubMed, Cochrane, Web of Science and Embase. Data were extracted upon quality assessment of included studies. Two reviewers conducted the screening process according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. Eighty-four studies met the search criteria and four randomized controlled trials were included in the meta-analysis, these were assessed for bias using Minors. Pooled completion rate of SBCE studies was defined as the primary outcome.
Results Three randomized controlled trials were SBCE studies and one was a CCE study. The pooled completion rate (91%) was not significantly higher in SBCE patients who were given chewing gum after capsule ingestion compared to those who were not (85%). Variance information was not reported in all studies, and therefore, pooled transit time estimates could not be calculated.
Conclusions Chewing gum has a good safety profile but has only been used as a booster in one CCE study and a few SBCE studies. More prospective randomized controlled trials, therefore, are needed to investigate the efficacy of chewing gum for achieving complete capsule examination.
Keywords
Endoscopy Small Bowel - Capsule endoscopy - Quality and logistical aspects - Preparation - Endoscopy Lower GI TractPublikationsverlauf
Eingereicht: 15. November 2023
Angenommen nach Revision: 05. April 2024
Artikel online veröffentlicht:
10. Juli 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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References
- 1 Spada C, Barbaro F, Andrisani G. et al. Colon capsule endoscopy: What we know and what we would like to know. World J Gastroenterol 2014; 20: 16948-16955
- 2 Adler SN, Hassan C, Metzger Y. et al. Second-generation colon capsule endoscopy is feasible in the out-of-clinic setting. Surg Endosc 2014; 28: 570-575
- 3 Bjørsum-Meyer T, Skonieczna-Zydecka K, Cortegoso Valdivia P. et al. Efficacy of bowel preparation regimens for colon capsule endoscopy: a systematic review and meta-analysis. Endosc Int Open 2021; 9: E1-E16
- 4 Bjørsum-Meyer T, Koulaouzidis A, Baatrup G. The optimal use of colon capsule endoscopes in clinical practice. Ther Adv Chronic Dis 2022; 13
- 5 Chen S, Guo LL, Zhong L. et al. Preparation of small bowel capsule endoscopy (SBCE) with simethicone: A meta-analysis. Clin Res Hepatol Gastroenterol 2022; 46: 102029
- 6 Marmo C, Riccioni ME, Pennazio M. et al. Small bowel cleansing for capsule endoscopy, systematic review and meta- analysis: Timing is the real issue. Dig Liver Dis 2023; 55: 454-463
- 7 Kaffes AJ. Achieving total enteroscopy with capsule endoscopy in all patients: are we stretching the limits of technology?. Gastrointest Endosc 2009; 69: 81-83
- 8 Singhal S, Nigar S, Paleti V. et al. Bowel preparation regimens for colon capsule endoscopy: a review. Therap Adv Gastroenterol 2014; 7: 115-122
- 9 Konturek SJ, Thor P. Relation between duodenal alkaline secretion and motility in fasted and sham-fed dogs. Am J Physiol 1986; 251: G591-G596
- 10 Katschinski M, Dahmen G, Reinshagen M. et al. Cephalic stimulation of gastrointestinal secretory and motor responses in humans. Gastroenterology 1992; 103: 383-391
- 11 Stern RM, Crawford HE, Stewart WR. et al. Sham feeding. Cephalic-vagal influences on gastric myoelectric activity. Dig Dis Sci 1989; 34: 521-527
- 12 Soffer EE, Adrian TE. Effect of meal composition and sham feeding on duodenojejunal motility in humans. Dig Dis Sci 1992; 37: 1009-1014
- 13 Schuster R, Grewal N, Greaney GC. et al. Gum chewing reduces ileus after elective open sigmoid colectomy. Arch Surg 2006; 141: 174-176
- 14 Page MJ, McKenzie JE, Bossuyt PM. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Rev Esp Cardiol (Engl Ed) 2021; 74: 790-799
- 15 [Anonym]. EndNote. San Francisco CA: Clarivate Analytics; 2018:
- 16 Stoll CRT, Izadi S, Fowler S. et al. The value of a second reviewer for study selection in systematic reviews. Res Synth Methods 2019; 10: 539-545
- 17 Slim K, Nini E, Forestier D. et al. Methodological index for non-randomized studies (minors): development and validation of a new instrument. ANZ J Surg 2003; 73: 712-716
- 18 Nyaga VN, Arbyn M, Aerts M. Metaprop: a Stata command to perform meta-analysis of binomial data. Arch Public Health 2014; 72: 39
- 19 Egger M, Davey Smith G, Schneider M. et al. Bias in meta-analysis detected by a simple, graphical test. BMJ (Clinical research ed) 1997; 315: 629-634
- 20 StataCorp . Stata Statistical Software: Release 17, College Station, TX: StataCorp LLC. 2021
- 21 Apostolopoulos P, Kalantzis C, Gralnek IM. et al. Clinical trial: effectiveness of chewing-gum in accelerating capsule endoscopy transit time--a prospective randomized, controlled pilot study. Aliment Pharmacol Therap 2008; 28: 405-411
- 22 Ou G, Svarta S, Chan C. et al. The effect of chewing gum on small-bowel transit time in capsule endoscopy: a prospective, randomized trial. Gastrointest Endosc 2014; 79: 630-636
- 23 Huang L, Hu Y, Chen F. et al. Effectiveness of improved use of chewing gum during capsule endoscopy in decreasing gastric transit time: A prospective randomized controlled study. Front Med (Lausanne) 2021; 8: 605393
- 24 Buijs MM, Kobaek-Larsen M, Kaalby L. et al. Can coffee or chewing gum decrease transit times in Colon capsule endoscopy? A randomized controlled trial. BMC Gastroenterol 2018; 18: 95
- 25 Dabos KJ, Giannakou A, Koulaouzidis A. Chewing gum and completion rate in small-bowel capsule endoscopy: meta-analyzing the data. Gastrointest Endosc 2014; 79: 1032-1034
- 26 Deding U, Jensen SS, Schelde-Olesen B. et al. Castor oil in bowel preparation regimens for colon capsule endoscopy: A systematic review with meta-analysis. Diagnostics (Basel) 2022; 12: 2795
- 27 Deding U, Kaalby L, Baatrup G. et al. The Effect of prucalopride on the completion rate and polyp detection rate of colon capsule endoscopies. Clin Epidemiol 2022; 14: 437-444
- 28 Kroijer R, Dyrvig AK, Kobaek-Larsen M. et al. Booster medication to achieve capsule excretion in colon capsule endoscopy: A randomized controlled trial of three regimens. Endosc Int Open 2018; 6: E1363-E1368