Erratum: Aktuelle und zukünftige pharmakologische Therapieoptionen zur Behandlung der Osteoporose und deren Wirkmechanismen – ein Überblick

Erratum

Aktuelle und zukünftige pharmakologische Therapieoptionen zur Behandlung der Osteoporose und deren Wirkmechanismen – ein Überblick

Fößl I, Obermayer-Pietsch B. Osteologie 2024; 33: 67–73.

DOI: 10.1055/a-2304-7012

Im oben genannten Artikel ist die Tab. 1 fehlerhaft. Die korrekte Tabelle ist unten abgebildet.

Tab. 1 Pharmakologische Behandlungsmöglichkeiten bei Osteoporose und deren präventiver Effekt auf verschiedene Frakturen mit den relevantesten Sicherheitsaspekten und Zulassungsmodalitäten, modifiziert nach [60]
Table 1 Pharmacological treatment options for osteoporosis and their preventive effect on different types of fractures, including relevant safety aspects and approvals, modified from [60].

Substanz	Dosierung	Applikation	Effekt auf vertebrale Frakturen	Effekt auf non-vertebrale Frakturen	Effekt auf Frakturen der Hüfte	Relevanteste Sicherheits-aspekte	Zulassung für	Referenzen
Alendronata	10mg täglich; 70mg wöchentlich	Oral	+	+	+	Reizungen der Magenschleimhaut, Anstieg von Kreatinin, MRONJ, AFF	Frauen und Männer; GIOP	[64] [65] [66] [67]
Risedronata	5mg täglich; 35mg wöchentlich	Oral	+	+	+		Frauen und Männer	[68] [69] [70] [71]
Ibandronatb	3mg alle 3 Monate intravenös oder 150mg einmal monatlich oral	Intravenös oder oral	+	+	-		Frauen	[72] [73] [74] [75]
Zoledronat	5mg	Intravenös	+	+	+		Frauen und Männer; GIOP; Morbus Paget	[76] [77]
Raloxifen	60 mg	Oral	+	+ c	-	Hitzewallungen, tiefe Venenthrombosen, Lungenembolien, Netzhautvenenthrombosen	Frauen	[78] [79] [80]
Bazedoxifen	20 mg	Oral	+	+ / - d	-		Frauen	[16, 81] [82] [83] [84]
Teriparatid	20 µg täglich für max 2 years	Subkutan	+	+	-	Hyperkalzämie, Hyperkalziurie, Hyperurikämie, Osteosarkom, orthostatische Hypotension	Frauen und Männer; GIOP	[21, 85]
Abaloparatid	80 µg täglich bei maximal totaler Verabreichungsdauer von 18 Monaten	Subkutan	+	+	+		In der EU zugelassen für Frauen; in den USA zugelassen für Frauen und Männer	[86] [87] [88] [89]
Denosumab	60mg alle 6 Monate	Subkutan	+	+	+	Hypokalzämie, Wirbelfrakturen, MRONJ, AFF, Nierenschädigung, Hautinfektionen	Frauen und Männer, MHA, GIOP	[90] [91]
Romosozumab	210mg monatlich für 1 Jahr	Subkutan	+	+	+	Kardiovaskuläre (im Vergleich mit Alendronat)	Frauen	[92] [93]
MHT / HRTf	Abhängig vom Therapieziel	Abhängig von Substanz und Indikation	+	+	+	Venöse Thromboembolien, Lungenembolien, Brustkrebs	NA	[94] [95] [96] [97] [98] [99] [100] [101]

+ Die Substanz zeigt eine Wirkung auf die jeweilige Fraktur; - die Substanz zeigt keine bekannte Wirkung auf die jeweilige Fraktur; ± die Substanz zeigt kontroverse Studienergebnisse in Bezug auf die jeweilige Fraktur. AFF, atypische Femurfraktur; EU, Europäische Union; GIOP, Glukokortikoid-induzierte Osteoporose; HRT, Hormonersatztherapie; MHA, Knochenverlust in Verbindung mit Hormonablation bei Männern mit Prostatakrebs und erhöhtem Frakturrisiko; MHT, postmenopausale Hormontherapie; MRONJ, medikamentenbedingte Osteonekrose des Kiefers. ^aKeine direkten Belege für die frakturhemmende Wirksamkeit bei einmal wöchentlicher Verabreichung. ^bKeine direkten Belege für die frakturhemmende Wirksamkeit bei vierteljährlicher intravenöser Verabreichung von 3 mg. ^cBei PatientInnen mit vorbestehender schwerer Wirbelfraktur. ^dKontroverse Ergebnisse.. fFrakturinzidenz kein primärer Endpunkt.

Publication History

Article published online:
26 July 2024

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