Direct endoscopic necrosectomy: Pilot study of a new dedicated device

Dario Ligresti; Cecilia Binda; Alessandro Fugazza; Marcello Maida; Mario Traina; Andrea Anderloni; Carlo Fabbri; Ilaria Tarantino

doi:10.1055/a-2376-1913

Endoscopy International Open, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Endosc Int Open 2024; 12(08): E962-E967
DOI: 10.1055/a-2376-1913

Innovation forum

Direct endoscopic necrosectomy: Pilot study of a new dedicated device

Dario Ligresti

¹Digestive Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT, Palermo, Italy

,

Cecilia Binda

²Unit of Gastroenterology and Digestive Endoscopy, Morgagni-Pierantoni Hospital, Forli, Italy (Ringgold ID: RIN18568)

³Unit of Gastroenterology and Digestive Endoscopy, Maurizio Bufalini Hospital, Cesena, Italy (Ringgold ID: RIN161128)

,

Alessandro Fugazza

⁴Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Research Hospital, Rozzano, Italy

,

Marcello Maida

⁵Department of Medicine and Surgery, Università degli Studi di Enna 'Kore', Enna, Italy (Ringgold ID: RIN217140)

⁶Gastroenterology Unit, Umberto I Hospital, Enna, Italy (Ringgold ID: RIN73129)

,

Mario Traina

¹Digestive Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT, Palermo, Italy

,

Andrea Anderloni

⁷Gastroenterology and Digestive Endoscopy Unit, Viale Camillo Golgi, 19, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia (PV) 27100, Italy

,

Carlo Fabbri

⁸Digestive Endoscopy and Gastroenterology Unit, Forlì-Cesena Hospitals, Azienda Unita Sanitaria Locale della Romagna, Forlì-Cesena, Italy (Ringgold ID: RIN390233)

,

Ilaria Tarantino

¹Digestive Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT, Palermo, Italy

› Institutsangaben

Abstract

Background and study aims Direct endoscopic necrosectomy (DEN) represents the first-line treatment for walled-off necrosis (WON). However, DEN has a non-negligible rate of overall adverse events (AE) and is time-consuming due to the lack of dedicated devices. This pilot study was designed to evaluate the feasibility and safety of a novel dedicated device for DEN named Necrolit.

Patients and methods In this multicenter retrospective analysis,16 patients with WON who underwent DEN using Necrolit were compared with a control group treated with non-dedicated devices. Technical success, AEs, clinical success, number of procedures per patient, procedure time, and length of hospital stay were evaluated. Necrolit technical performance indicators were also studied.

Results Technical success was obtained in all patients in both groups. In the Necrolit group, the overall AE rate was 10.1% vs. 15.9% in the control group. Clinical success was 100% in the Necrolit group vs. 81.3% in the control group. Patients treated with Necrolit underwent a slightly lower mean number of procedures (4.1 ± 2.3 vs. 5.1 ± 1.9) with comparable mean procedure time (67.8 ± 39 minutes vs. 70.1 ± 32.6 minutes). Mean duration of hospital stay was 39.4 days (± 30.9) in the Necrolit group vs. 43 days (± 29.4) in the control group. Device-related technical performance was rated positively.

Conclusions DEN with Necrolit appears feasible and safe.

Keywords

Endoscopic ultrasonography - Intervention EUS - Pancreas

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Referenzen

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