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Diabetologie und Stoffwechsel 2024; 19(05): 325-327
DOI: 10.1055/a-2384-6040
DDG-Preisträger

Virusinfektionen und Typ-1-Diabetes: neue diagnostische und therapeutische Ansätze

Hellmut-Otto-Medaille 2024 – Kurzübersicht des Preisträgers Stefan Bornstein
Stefan R. Bornstein
,
Nikolaos Perakakis
,
Charlotte Steenblock 
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Typ-1-Diabetes, der aus der autoimmunen Zerstörung von β-Zellen resultiert, ist eine schwere Krankheit, nicht nur wegen der belastenden Spätkomplikationen, die zu einer verkürzten Lebenserwartung führen, sondern auch aufgrund der hohen täglichen Belastung, die durch die Anforderungen der Insulintherapie auf die Patienten und ihre Familien ausgeübt wird. Trotz intensiver biochemischer, immunologischer, epidemiologischer und klinischer Forschung in den letzten 100 Jahren ist die Ätiologie von Typ-1-Diabetes weitgehend noch nicht geklärt. Es scheint das Ergebnis eines komplexen Zusammenspiels zwischen genetischer Veranlagung, dem Immunsystem und Umweltfaktoren zu sein.



Publication History

Article published online:
09 October 2024

© 2024. Thieme. All rights reserved.

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  • Literatur

  • 1 Lemos JRN, Hirani K, von Herrath M. Immunological and virological triggers of type 1 diabetes: insights and implications. Front Immunol 2023; 14: 1326711
    CrossrefPubMedSearch in Google Scholar
  • 2 Perakakis N, Harb H, Hale BG. et al. Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases. Lancet Diabetes Endocrinol 2023; 11: 675-693
    CrossrefPubMedSearch in Google Scholar
  • 3 Nielsen PR, Kragstrup TW, Deleuran BW. et al. Infections as risk factor for autoimmune diseases – A nationwide study. J Autoimmun 2016; 74: 176-181
    CrossrefPubMedSearch in Google Scholar
  • 4 Yeung WC, Rawlinson WD, Craig ME. Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies. BMJ 2011; 342: d35
    CrossrefPubMedSearch in Google Scholar
  • 5 Richardson SJ, Leete P, Bone AJ. et al. Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1. Diabetologia 2013; 56: 185-193
    CrossrefPubMedSearch in Google Scholar
  • 6 Ylipaasto P, Klingel K, Lindberg AM. et al. Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured islet beta cells. Diabetologia 2004; 47: 225-239
    CrossrefPubMedSearch in Google Scholar
  • 7 Oikarinen M, Tauriainen S, Oikarinen S. et al. Type 1 diabetes is associated with enterovirus infection in gut mucosa. Diabetes 2012; 61: 687-691
    CrossrefPubMedSearch in Google Scholar
  • 8 Schulte BM, Bakkers J, Lanke KH. et al. Detection of enterovirus RNA in peripheral blood mononuclear cells of type 1 diabetic patients beyond the stage of acute infection. Viral Immunol 2010; 23: 99-104
    CrossrefPubMedSearch in Google Scholar
  • 9 Colli ML, Nogueira TC, Allagnat F. et al. Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance. PLoS Pathog 2011; 7: e1002267
    CrossrefPubMedSearch in Google Scholar
  • 10 Ylipaasto P, Smura T, Gopalacharyulu P. et al. Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction. Diabetologia 2012; 55: 3273-3283
    CrossrefPubMedSearch in Google Scholar
  • 11 Oshima M, Knoch KP, Diedisheim M. et al. Virus-like infection induces human beta cell dedifferentiation. JCI Insight 2018; 3: e97732
    CrossrefPubMedSearch in Google Scholar
  • 12 Petzold A, Solimena M, Knoch KP. Mechanisms of Beta Cell Dysfunction Associated With Viral Infection. Curr Diab Rep 2015; 15: 73
    CrossrefPubMedSearch in Google Scholar
  • 13 Op de Beeck A, Eizirik DL. Viral infections in type 1 diabetes mellitus--why the beta cells?. Nat Rev Endocrinol 2016; 12: 263-723
    CrossrefPubMedSearch in Google Scholar
  • 14 Schloot NC, Willemen SJ, Duinkerken G. et al. Molecular mimicry in type 1 diabetes mellitus revisited: T-cell clones to GAD65 peptides with sequence homology to Coxsackie or proinsulin peptides do not crossreact with homologous counterpart. Hum Immunol 2001; 62: 299-309
    CrossrefPubMedSearch in Google Scholar
  • 15 Chehadeh W, Kerr-Conte J, Pattou F. et al. Persistent infection of human pancreatic islets by coxsackievirus B is associated with alpha interferon synthesis in beta cells. J Virol 2000; 74: 10153-10164
    CrossrefPubMedSearch in Google Scholar
  • 16 Krogvold L, Mynarek IM, Ponzi E. et al. Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial. Nat Med 2023; 29: 2902-2908
    CrossrefPubMedSearch in Google Scholar
  • 17 Dahl-Jorgensen K. Virus as the cause of type 1 diabetes. Trends Mol Med 2024; 13: S1471
    CrossrefPubMedSearch in Google Scholar
  • 18 Hirani D, Salem V, Khunti K. et al. Newly detected diabetes during the COVID-19 pandemic: What have we learnt?. Best Pract Res Clin Endocrinol Metab 2023; 37: 101793
    CrossrefPubMedSearch in Google Scholar
  • 19 Steenblock C, Hassanein M, Khan EG. et al. Diabetes and COVID-19: Short- and Long-Term Consequences. Horm Metab Res 2022; 54: 503-509
    Thieme ConnectPubMedSearch in Google Scholar
  • 20 Weiss A, Donnachie E, Beyerlein A. et al. Type 1 Diabetes Incidence and Risk in Children With a Diagnosis of COVID-19. Jama 2023; 329: 2089-2091
    CrossrefPubMedSearch in Google Scholar
  • 21 Lugar M, Eugster A, Achenbach P. et al. SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood. Jama 2023; 330: 1151-1160
    CrossrefPubMedSearch in Google Scholar
  • 22 Muller JA, Gross R, Conzelmann C. et al. SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nat Metab 2021; 3: 149-165
    CrossrefPubMedSearch in Google Scholar
  • 23 Tang X, Uhl S, Zhang T. et al. SARS-CoV-2 infection induces beta cell transdifferentiation. Cell Metab 2021; 33: 1577-1591 e7
    CrossrefPubMedSearch in Google Scholar
  • 24 Steenblock C, Richter S, Berger I. et al. Viral infiltration of pancreatic islets in patients with COVID-19. Nat Commun 2021; 12: 3534
    CrossrefPubMedSearch in Google Scholar
  • 25 Stein SR, Ramelli SC, Grazioli A. et al. SARS-CoV-2 infection and persistence in the human body and brain at autopsy. Nature 2022; 612: 758-763
    CrossrefPubMedSearch in Google Scholar
  • 26 Ryan PM, Caplice NM. Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019?. Obesity (Silver Spring) 2020; 28: 1191-1194
    CrossrefPubMedSearch in Google Scholar
  • 27 Saccon TD, Mousovich-Neto F, Ludwig RG. et al. SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner. Nat Commun 2022; 13: 5722
    CrossrefPubMedSearch in Google Scholar
  • 28 Steenblock C, Bechmann N, Beuschlein F. et al. Do adipocytes serve as a reservoir for severe acute respiratory symptom coronavirus-2?. J Endocrinol 2023; 258: e230027
    CrossrefPubMedSearch in Google Scholar
  • 29 Zickler M, Stanelle-Bertram S, Ehret S. et al. Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans. Cell Metab 2022; 34: 1-2
    CrossrefPubMedSearch in Google Scholar