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Semin Liver Dis 2024; 44(03): 343-355
DOI: 10.1055/a-2404-7973
Review Article

Hepatic Extracellular Matrix and Its Role in the Regulation of Liver Phenotype

Gavin E. Arteel
1   Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
2   Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania
› Author Affiliations Financial Support This work was supported, in part, by grants from NIH (R01 AA021978 and P30 DK120531).
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Abstract

The hepatic extracellular matrix (ECM) is most accurately depicted as a dynamic compartment that comprises a diverse range of players that work bidirectionally with hepatic cells to regulate overall homeostasis. Although the classic meaning of the ECM referred to only proteins directly involved in generating the ECM structure, such as collagens, proteoglycans, and glycoproteins, the definition of the ECM is now broader and includes all components associated with this compartment. The ECM is critical in mediating phenotype at the cellular, organ, and even organismal levels. The purpose of this review is to summarize the prevailing mechanisms by which ECM mediates hepatic phenotype and discuss the potential or established role of this compartment in the response to hepatic injury in the context of steatotic liver disease.

Keywords

extracellular matrix - matrisome - hepatic - liver disease


Publication History

Accepted Manuscript online:
27 August 2024

Article published online:
17 September 2024

© 2024. Thieme. All rights reserved.

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