Translational Perspectives on the Therapeutic Potential of Hyptis Crenata Essential Oil Terpenes in Smooth Muscle Function

André Nogueira Cardeal dos Santos; José Ednésio da Cruz Freire; Bruna Ferreira Rodrigues; Francisco Walber Ferreira-da-Silva; José Eduardo Ribeiro Honório Júnior; José Henrique Leal Cardoso; Andrelina Noronha Coelho de Souza

doi:10.1055/a-2409-3735

Planta Medica, Table of Contents

Planta Med 2024; 90(13): 1005-1014
DOI: 10.1055/a-2409-3735

Biological and Pharmacological Activity

Reviews

Translational Perspectives on the Therapeutic Potential of Hyptis Crenata Essential Oil Terpenes in Smooth Muscle Function

André Nogueira Cardeal dos Santos

¹Experimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Ceará, Brazil

,

José Ednésio da Cruz Freire

²Biochemistry and Gene Expression Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Ceará, Brazil

,

Bruna Ferreira Rodrigues

¹Experimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Ceará, Brazil

,

Francisco Walber Ferreira-da-Silva

³Electrophysiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Ceará, Brazil

,

José Eduardo Ribeiro Honório Júnior

⁴Neuroscience and Translational Medicine Laboratory, Christus University Center, Fortaleza, Ceará, Brazil

,

José Henrique Leal Cardoso

³Electrophysiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Ceará, Brazil

,

Andrelina Noronha Coelho de Souza

¹Experimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Ceará, Brazil

› Author Affiliations

Abstract

Monoterpenes and sesquiterpenes are classes of organic compounds found in various natural products, such as the essential oil of Hyptis crenata (EOHc). The therapeutic potential of these terpenes present in EOHc is evidenced by their effect on smooth muscle and potential clinical applications. Among the highlighted monoterpenes, such as sabinene, α-pinene, and β-pinene, a relaxing effect on rat intestinal smooth muscles is observed, attributed to interaction with calcium channels. Furthermore, monoterpenoids like borneol, cineole, and linalool also demonstrate vasorelaxant properties, suggesting potential in the treatment of cardiovascular conditions. Sesquiterpenes, such as caryophyllene and aromadendrenes, exhibit relaxing effects in various smooth muscle tissues, such as rat uterus and guinea pig ileum, indicating pharmacological potential in these areas. The translational exploration of targets, such as calcium channels and G protein-coupled receptors, highlights the importance of these compounds in discovering new therapies based on natural products for treating various medical conditions.

Keywords

Hyptis crenata - Lamiaceae - monoterpenes and sesquiterpenes - effect on smooth muscle - biomedical applications

Full Text

References

References
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