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Planta Med 2024; 90(13): 1005-1014
DOI: 10.1055/a-2409-3735
Biological and Pharmacological Activity
Reviews

Translational Perspectives on the Therapeutic Potential of Hyptis Crenata Essential Oil Terpenes in Smooth Muscle Function

André Nogueira Cardeal dos Santos
1   Experimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Ceará, Brazil
,
José Ednésio da Cruz Freire
2   Biochemistry and Gene Expression Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Ceará, Brazil
,
Bruna Ferreira Rodrigues
1   Experimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Ceará, Brazil
,
Francisco Walber Ferreira-da-Silva
3   Electrophysiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Ceará, Brazil
,
José Eduardo Ribeiro Honório Júnior
4   Neuroscience and Translational Medicine Laboratory, Christus University Center, Fortaleza, Ceará, Brazil
,
José Henrique Leal Cardoso
3   Electrophysiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Ceará, Brazil
,
Andrelina Noronha Coelho de Souza
1   Experimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Ceará, Brazil
› InstitutsangabenThis work was supported by research grants from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and the Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP). We also acknowledge the Superior Institute of Biomedical Sciences – State University of Ceará, Fortaleza, CE, Brazil, and the Christus University Center – Unichristus, Fortaleza, CE, Brazil, for supporting this research, although not financially.
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Abstract

Monoterpenes and sesquiterpenes are classes of organic compounds found in various natural products, such as the essential oil of Hyptis crenata (EOHc). The therapeutic potential of these terpenes present in EOHc is evidenced by their effect on smooth muscle and potential clinical applications. Among the highlighted monoterpenes, such as sabinene, α-pinene, and β-pinene, a relaxing effect on rat intestinal smooth muscles is observed, attributed to interaction with calcium channels. Furthermore, monoterpenoids like borneol, cineole, and linalool also demonstrate vasorelaxant properties, suggesting potential in the treatment of cardiovascular conditions. Sesquiterpenes, such as caryophyllene and aromadendrenes, exhibit relaxing effects in various smooth muscle tissues, such as rat uterus and guinea pig ileum, indicating pharmacological potential in these areas. The translational exploration of targets, such as calcium channels and G protein-coupled receptors, highlights the importance of these compounds in discovering new therapies based on natural products for treating various medical conditions.

Keywords

Hyptis crenata - Lamiaceae - monoterpenes and sesquiterpenes - effect on smooth muscle - biomedical applications


Publikationsverlauf

Eingereicht: 06. Juni 2024

Angenommen nach Revision: 03. September 2024

Accepted Manuscript online:
03. September 2024

Artikel online veröffentlicht:
23. September 2024

© 2024. Thieme. All rights reserved.

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