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CC BY 4.0 · European J Pediatr Surg Rep. 2024; 12(01): e73-e76
DOI: 10.1055/a-2430-0053
Case Report

Pulmonary Inflammatory Myofibroblastic Tumor: A Case Report

Lotte Bruyninckx
1   Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
,
Paul De Leyn
1   Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
,
Dirk Van Raemdonck
1   Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
,
Yanina Jansen
1   Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
,
Katrien Coppens
2   Department of Paediatrics, Imelda Hospital, Bonheiden, Belgium
,
Francois Vermeulen
3   Department of Paediatrics, University Hospitals Leuven, Leuven, Vlaams-Brabant, Belgium
,
Birgit Weynand
4   Department of Pathology, University Hospitals Leuven, Leuven, Vlaams-Brabant, Belgium
,
Christopher Gieraerts
5   Department of Radiology, Imelda Hospital, Bonheiden, Belgium
,
Herbert Decaluwé
1   Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
6   Department of Thoracovascular Surgery, Ziekenhuis Oost-Limburg, Genk, Limburg, Belgium
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Abstract

An inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor that occurs predominantly in children and young adults. Etiology remains unclear. But based on the frequent detection of chromosomic alterations, especially near the anaplastic lymphoma kinase (ALK) gene, IMT is now considered to be a true neoplasm. In addition, the possible aggressive behavior, and the ability to metastasize suggest at least an intermediate malignant potential. Surgery remains the treatment of choice, but the use of chemotherapy, nonsteroidal anti-inflammatory drugs, immunotherapy, and targeted therapy are reported. We describe a case of a pulmonary IMT in a 6-year-old boy with an incidental finding of a lesion in the right upper lobe. A video-assisted thoracoscopic right upper lobectomy with lymph node resection was performed. Microscopic examination confirmed the diagnosis of IMT with the nodule showing spindle cells in a background of plasma cells. ALK immunohistochemical expression was negative.

Keywords

inflammatory myofibroblastic tumor - histopathology - anaplastic lymphoma kinase - pediatric surgery


Publication History

Received: 03 December 2023

Accepted: 17 September 2024

Accepted Manuscript online:
01 October 2024

Article published online:
04 November 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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