CC BY-NC-ND 4.0 · Endosc Int Open 2024; 12(11): E1295-E1302
DOI: 10.1055/a-2438-7223
Original article

Non-neoplastic findings in colon capsule endoscopy: Additional yield

1   Department of Clinical Research, University of Southern Denmark, Odense, Denmark (Ringgold ID: RIN6174)
2   Research Unit of Surgery, Odense University Hospital, Svendborg, Denmark (Ringgold ID: RIN11286)
,
Lasse Kaalby
1   Department of Clinical Research, University of Southern Denmark, Odense, Denmark (Ringgold ID: RIN6174)
2   Research Unit of Surgery, Odense University Hospital, Svendborg, Denmark (Ringgold ID: RIN11286)
,
1   Department of Clinical Research, University of Southern Denmark, Odense, Denmark (Ringgold ID: RIN6174)
2   Research Unit of Surgery, Odense University Hospital, Svendborg, Denmark (Ringgold ID: RIN11286)
,
Anastasios Koulaouzidis
1   Department of Clinical Research, University of Southern Denmark, Odense, Denmark (Ringgold ID: RIN6174)
2   Research Unit of Surgery, Odense University Hospital, Svendborg, Denmark (Ringgold ID: RIN11286)
,
1   Department of Clinical Research, University of Southern Denmark, Odense, Denmark (Ringgold ID: RIN6174)
2   Research Unit of Surgery, Odense University Hospital, Svendborg, Denmark (Ringgold ID: RIN11286)
› Author Affiliations

Abstract

Background and study aims Despite the common occurrence of non-neoplastic findings (NNFs) in individuals with a positive fecal immunochemical test (FIT), few studies have reported on these findings. The aim of this cross-sectional study was to determine the prevalence of colonic NNFs in three cohorts of Danish clinical trial participants who underwent colon capsule endoscopy (CCE).

Patients and methods Retrospectively collecting NNFs from CCE reports of three Danish trials, we classified them into five categories: diverticula, vascular abnormalities, inflammation, erosions/ulcerations, and others. The statistical analysis included 516 participants from three trials, with a mean age ranging from 59.2 to 63.9 years. The participants in the three trials were FIT-positive screening or symptomatic individuals.

Results NNFs were reported in more than half of the CCE procedures (50.6% to 77.9%), with colonic diverticula being the most common NNF appearing in 40.9% to 66.9% of the CCE reports. Vascular abnormalities and erosions/ulcerations were also common depending on the specific trial.

Conclusions NNFs are common and may be an indicator of more widespread disease. Furthermore, NNFs may develop into clinically significant conditions despite their benign appearance. This paper expands on the limited literature about prevalence of NNFs and underscores the additional value of CCE video recordings beyond detecting polyps.



Publication History

Received: 30 April 2024

Accepted after revision: 09 September 2024

Article published online:
07 November 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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