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DOI: 10.1055/a-2460-7378
Graphical Review

Transition Metal Catalyzed Deuteration via Hydrogen Isotope Exchange

Zhi-Jiang Jiang 
1   School of Biological and Chemical Engineering, NingboTech University, Ningbo, China (Ringgold ID: RIN199200)
,
Jian-Fei Bai
1   School of Biological and Chemical Engineering, NingboTech University, Ningbo, China (Ringgold ID: RIN199200)
,
Zhanghua Gao 
1   School of Biological and Chemical Engineering, NingboTech University, Ningbo, China (Ringgold ID: RIN199200)
› Author AffiliationsSupported by: Science and Technology Innovation 2025 Major Project of Ningbo Municipality 2020Z092
Supported by: Natural Science Foundation of Ningbo Municipality 202003N4310
Supported by: National Natural Science Foundation of China 22001257,22308307
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Direct hydrogen isotope exchange represents a distinctive strategy for deuterium labelling, where the protium is directly replaced by deuterium. In this graphic review, we summarized the progress in deuteration via transition metal catalyzed hydrogen isotope exchange. The review was organized according to the mechanism of C-H bond activation in the homogeneous catalysis, and the heterogeneous catalysis was also discussed according to the catalyst type. Representative mechanistic processes were depicted, and proven cases for tritiation were also highlighted.



Publication History

Received: 20 September 2024

Accepted after revision: 29 October 2024

Accepted Manuscript online:
04 November 2024

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