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CC BY 4.0 · SynOpen 2024; 08(04): 387-400
DOI: 10.1055/a-2501-4247
DOI: 10.1055/a-2501-4247
graphical review
Transition-Metal-Catalyzed Asymmetric Reduction of 2-Pyridine Ketones
This work was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) (Discovery Grant RGPIN-2023-03591), the FRQNT Centre in Green Chemistry and Catalysis (CGCC) Strategic Cluster FRQNT-2020-RS4-265155-CCVC, and Université Laval. V.V and H.M.S. thank MITACS for Globalink Research Innovation award scholarships.
Abstract
This graphical review provides a concise overview of transition-metal-catalyzed asymmetric reduction of 2-pyridine ketones to produce enantiopure chiral 2-pyridine aryl/alkyl alcohols, which are present in many chiral ligands and pharmaceuticals. Key methods include metal-catalyzed hydrogenation, transfer hydrogenation, and hydrosilylation, with a focus on sustainable catalysts like iron and manganese. This review serves as a foundation for future advancements in sustainable and enantioselective keto group reductions.
Key words
asymmetric reduction - ketones - transfer hydrogenation - hydrogenation - hydrosilylation - iron catalysisPublication History
Received: 08 November 2024
Accepted after revision: 11 December 2024
Accepted Manuscript online:
13 December 2024
Article published online:
19 December 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)
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