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Synthesis
DOI: 10.1055/a-2503-2459
review

Spirocyclizations of Nortropanes

Oleg Lukin 
1   I.F. Lab Ltd., Life Chemicals Inc, Kyiv, Ukraine (Ringgold ID: RIN506091)
,
Alexander Shivanyuk 
2   Research and Development, Life Chemicals Kyiv, Kyiv, Ukraine (Ringgold ID: RIN503942)
,
Grygoriy Dolgonos
3   Representative office in Kyiv, Life Chemicals Inc, Kyiv, Ukraine (Ringgold ID: RIN506091)
,
Andrii Gerasov
2   Research and Development, Life Chemicals Kyiv, Kyiv, Ukraine (Ringgold ID: RIN503942)
,
Alexandr Mandzhulo
2   Research and Development, Life Chemicals Kyiv, Kyiv, Ukraine (Ringgold ID: RIN503942)
,
Volodymyr Fetyukhin
2   Research and Development, Life Chemicals Kyiv, Kyiv, Ukraine (Ringgold ID: RIN503942)
› Author AffiliationsSupported by: IF Lab Ltd 00050z-01737
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The shape-persistent bicyclic nortropane fragment is frequently found in both natural remedies and synthetic drugs. Herein we review synthetic approaches towards spirocyclic nortropanes, as well as their studied stereochemical properties and biological activity. 1 Introduction 2 Spiro-hybrids of nortropane with three-membered cycles 3 Spiro-hybrids of nortropane with four-membered cycles 4 Spiro-hybrids of nortropane with five-membered cycles 5 Spiro-hybrids of nortropane with six-membered and larger cycles 6 Conclusion



Publication History

Received: 26 September 2024

Accepted after revision: 16 December 2024

Accepted Manuscript online:
16 December 2024

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