PDF herunterladen
Synlett
DOI: 10.1055/a-2535-1306
account

Bioactive Molecules - via - Baylis-Hillman Chemistry

vaidya Jayathirtharao
1   Crop Protection Chemicals Division, Indian Institute of Chemical Technology, Hyderabad, India (Ringgold ID: RIN62391)
,
N.S. Sai Pavan Kumar Ch
2   Department of Chemistry, Vignan’s Foundation for Science, Technology & Research (Deemed to be University),, Vadlamudi, India
› Institutsangaben
› Weitere Informationen
  als PDF herunterladen Alle Artikel dieser Rubrik

Abstract Baylis-Hillman chemistry is applied to make variety of new chemical entities for the purpose of evaluating them towards their bioactivity. Various substances synthesized via BH chemistry are subjected towards (i) antimalarial; (ii) anti-inflammatory; (iii) antidiabetic; (iv) antimicrobial; (v) anti tubercular; (vi) phosphodiesterase inhibitors; and (vii) anticancer activities. Couple of instances animal model and biology studies explored. Several hits and lead molecules are identified and their IC50 values listed. The simplicity of Baylis-Hillman chemistry provides a realistic evaluation towards pharma industries. The work presented on this subject will definitely have an impact over pharmaceutical companies.



Publikationsverlauf

Eingereicht: 11. Dezember 2024

Angenommen nach Revision: 07. Februar 2025

Accepted Manuscript online:
07. Februar 2025

© . Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany