Ex Vivo Evaluation Of A Novel Through-The-Scope Traction Device For Endoscopic Submucosal Dissection

Background and study aims: Endoscopic submucosal dissection (ESD) is a technique used for the resection of large neoplastic lesions, providing great oncological outcomes. However, ESD is technically challenging with a long learning curve, high complication rates, and extended procedural times. To address these limitations, various traction-assisted methods have been developed. The study evaluates a novel through-the-scope traction device (TRACMOTION, Fujifilm, Japan) which offers consistent and adjustable traction, in a pilot multicenter randomized ex vivo trial. Patients and Methods: The study included six endoscopists with limited ESD experience performing ESD on ex vivo porcine stomach models. Participants were randomized into two groups: those using TRACMOTION-assisted ESD (TM-ESD) and those performing conventional ESD (C-ESD). Each trainee completed six procedures, split equally between both groups. Primary outcome was the resection speed, while secondary outcomes included en bloc, R0 resection rates, perforation rates, and rates of speedy procedures (>20 mm²/min) Results: TM-ESD group achieved a higher median resection speed of 20.75 mm²/min (95%CI 14.56-29.25) in comparison to 15.10 mm²/min (95%CI 12.8-16.6)) in the C-ESD group (p= 0.02). Perforation rates were significantly lower in the TM-ESD group (11.1% (95% CI 0.01-0.34) vs. 61.1% (95% CI 0.35-0.82; p=0.0002). No significant differences were observed in en bloc or R0 resection rates between the groups. Conclusions: TRACMOTION significantly improves the efficiency of ESD, reducing procedural time and complication rates. This traction device could potentially facilitate broader adoption of ESD in clinical practice. However, further research in human trials is necessary to validate these findings.

Publikationsverlauf

Eingereicht: 17. November 2024

Angenommen nach Revision: 27. März 2025

Accepted Manuscript online:
07. April 2025