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CC BY-NC-ND 4.0 · Endosc Int Open 2026; 14: a27815768
DOI: 10.1055/a-2781-5768
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A novel over-the-scope endoscopic assisting platform for expanding therapeutic capabilities: Preclinical feasibility study (with video)

Authors

  • Jie Xia‡

    1   Digestive Endoscopic Center, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

  • Muhan Li‡

    1   Digestive Endoscopic Center, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

  • Feifei Wang

    1   Digestive Endoscopic Center, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

  • Xincong Xi

    1   Digestive Endoscopic Center, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

  • Yueqin Qian

    1   Digestive Endoscopic Center, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

  • Xinjian Wan 

    1   Digestive Endoscopic Center, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

Supported by: The Hospital-level Research Project of Shanghai Sixth People‘s Hospital ynhg202223
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Abstract

The limitations of single-channel endoscopy in complex gastrointestinal disease prompted design of the over-the-scope endoscopic assisting platform (OTS-EAP), a low-profile cap that converts any diagnostic endoscope into a dual-channel therapeutic system. Ex-vivo bending tests and in-vivo porcine studies evaluated safety and feasibility for three tasks: 1) high-flow irrigation and suction of clot/chyme; 2) radiation-free, direct-visual stent delivery; and 3) purse-string closure of large endoscopic submucosal dissection defects. OTS-EAP preserved endoscope flexibility and torque; rapid valve-switching cleared the field within seconds, stents were deployed precisely under endoscopic view, and dual-instrument coordination simplified defect closure. The platform offers an inexpensive, radiation-sparing “third hand” for emergencies, bleeding, stenting, and suturing, warranting clinical translation.

Keywords

Endoscopy Upper GI Tract - Non-variceal bleeding - Endoscopic resection (ESD, EMRc, ...) - Dilation, injection, stenting

Supplementary Material



Publication History

Received: 19 September 2025

Accepted after revision: 05 January 2026

Accepted Manuscript online:
12 January 2026

Article published online:
27 January 2026

© 2026. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

Bibliographical Record
Jie Xia, Muhan Li, Feifei Wang, Xincong Xi, Yueqin Qian, Xinjian Wan. A novel over-the-scope endoscopic assisting platform for expanding therapeutic capabilities: Preclinical feasibility study (with video). Endosc Int Open 2026; 14: a27815768.
DOI: 10.1055/a-2781-5768
 

  • References

  • 1 Watanabe H, Adachi W, Koide N. et al. Food residue at endoscopy in patients who have previously undergone distal gastrectomy: risk factors and patient preparation. Endoscopy 2003; 35: 397-401
    Search in Google Scholar
  • 2 Barkun AN, Laine L, Leontiadis GI. et al. Management of Nonvariceal Upper Gastrointestinal Bleeding. Ann Intern Med 2020; 172: 573
    Search in Google Scholar
  • 3 Laine L, Barkun AN, Saltzman JR. et al. ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding. Am J Gastroenterol 2021; 116: 899-917
    Search in Google Scholar
  • 4 Zeng CY, Li GH, Zhu Y. et al. Single-channel endoscopic closure of large endoscopy-related perforations. Endoscopy 2015; 47: 735-738
    Search in Google Scholar
  • 5 Sun XG, Liu HZ, Zhang B. et al. Effect of endoscopic resection of gastrointestinal stromal tumors in the stomach under double-channel gastroscopy: A retrospective observational study. Medicine 2022; 101: e29941
    Search in Google Scholar
  • 6 Sulz MC, Bertolini R, Frei R. et al. Multipurpose use of the over-the-scope-clip system ("Bear claw") in the gastrointestinal tract: Swiss experience in a tertiary center. World J Gastroenterol 2014; 20: 16287-16292
    Search in Google Scholar
  • 7 Lopera JE, Brazzini A, Gonzales A. et al. Gastroduodenal stent placement: current status. Radiographics 2004; 24: 1561-1573
    Search in Google Scholar
  • 8 Maetani I, Tada T, Ukita T. et al. Comparison of duodenal stent placement with surgical gastrojejunostomy for palliation in patients with duodenal obstructions caused by pancreaticobiliary malignancies. Endoscopy 2004; 36: 73-78
    Search in Google Scholar
  • 9 Zhao L, Xu H, Zhang Y. Palliation double stenting for malignant biliary and duodenal obstruction. Experiment Therap Med 2016; 11: 348-352
    Search in Google Scholar
  • 10 Kim SH, Song HY, Park JH. et al. Fluoroscopic-guided stent placement in failed tentative endoscopic approaches to malignant gastroduodenal obstructions. Acta Radiologica (Stockholm, Sweden: 1987) 2017; 58: 959-963
    Search in Google Scholar