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Synlett
DOI: 10.1055/a-2796-1283
Letter

A J-resolved 13C–19F {1H, 19F} Experiment with Broadband Fluorine Decoupling for the Characterization of Polyfluorinated Organic Compounds

Authors

  • Jason Genova‡

    1   Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, United States

  • Rodrigo Cabrera Allpas‡

    1   Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, United States

  • David A. Nicewicz 

    1   Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, United States

  • Marc ter Horst

    1   Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, United States

Funding Information This material is based on work supported by the National Science Foundation under Grant No. CHE-2117287.
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Graphical Abstract

Abstract

We describe an approach to characterize polyfluorinated organic compounds via J-resolved 2D NMR. A shaped pulse was utilized to perform broadband decoupling of fluorine resonances with large chemical shifts, and the 13C–19F splitting patterns were visualized with proton decoupling. Through this, coupling constants ranging from single digits to as high as 274.0 Hz were easily visualized and displayed. Two organic compounds were analyzed with this technique and are discussed below.

Keywords

2D NMR - 19F, J-resolved - Shaped pulses - Broadband decoupling

Supplementary Material



Publication History

Received: 10 December 2025

Accepted after revision: 23 January 2026

Accepted Manuscript online:
26 January 2026

Article published online:
06 February 2026

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