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Synlett 2008(18): 2811-2814  
DOI: 10.1055/s-0028-1083548
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Alternative I-D Exchange Reaction on Pyrimidine and Purine Nuclei Mediated by Tributyltin Hydride Using THF-d 8 as a Deuterium Source

Tomonobu Mutsumi*a,b, Kazuo Maruhashia, Yasunari Monguchib, Hironao Sajikib
a Chemical Technology Laboratory, Taiho Pharmaceutical Co., Ltd., 200-22 Kodama-Gun, Saitama 367-0241, Japan
Fax: +81(495)774598; e-Mail: t-mutsumi@taiho.co.jp;
b Department of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan
Further Information

Publication History

Received 2 July 2008
Publication Date:
15 October 2008 (online)

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Abstract

A method for the regioselective deuteration of pyrimidine and purine rings mediated by Bu3SnH using THF-d 8 as a deuterium source on the basis of a radical reaction was developed.

Key words

regioselective deuteration - pyrimidine - purine - THF-d 8 - tributyltin hydride

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