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Synfacts 2009(1): 0105-0105
DOI: 10.1055/s-0028-1087249
DOI: 10.1055/s-0028-1087249
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Hydrogen-Transfer Reaction with Polymer-Supported Ru Catalysts
Y. Arakawa, A. Chiba, N. Haraguchi, S. Itsuno*
Toyohashi University of Technology, Japan
Further Information
Publication History
Publication Date:
18 December 2008 (online)
![](https://www.thieme-connect.de/media/synfacts/200901/lookinside/thumbnails/10.1055-s-0028-1087249-1.jpg)
Significance
The polymer-supported chiral 1,2-diamine monosulfonamides 4 and 5 were prepared by reaction of 1, 2, and 3 with AIBN in DMF. The asymmetric hydrogen-transfer reaction of ketones with the polymer-supported ligand (1.2 mol% of 4 or 5), [RuCl2(p-cymene)]2 (0.5 mol% of Ru) and HCO2Na in water gave the corresponding alcohols in 46-100% conversion and 60-99% ee values.