DOI: 10.1055/s-00000131

Synfacts

Issue 02 · Volume 21 · February 2025 DOI: 10.1055/s-015-60968

Synthesis of Natural Products

z111
All PDFs of this category
111
Total Synthesis of (±)-Phaeocaulisin A
112
Total Synthesis of (–)-Norzoanthamine
113
Synthesis of (–)-Cucurbalsaminone B
114
Total Synthesis of (–)-Cordycicadin D
115
Total Synthesis of Atropoisomeric (–)-Narcipavline
116
Chemoenzymatic Synthesis of (+)-Resibufogenin
117
Synthesis of (±)-Scopadulcic Acid B

Synthesis of Heterocycles

z119
All PDFs of this category
119
Rhodium-Catalyzed One-Carbon Ring Expansion of Aziridines for the Synthesis of 2-Vinyl Azetidines
120
Cobalt-Catalyzed Alkylarylation towards Csp3-Rich N-Heterocycles
121
Dearomatization is Temporary, Fluorination is Forever: C3-Selective Fluorination of Pyridine Adducts
122
Dearomative 1,2-Dicyanation of N-Heteroarenes: A Pathway for Accessing Non-Planar N-Heterocycles
123
Switchable Copper-Catalyzed γ-Lactamization and γ-Iminolactonization
124
Synthesis of Alkyl-Phosphonates from Alcohols
125
CN2-Transfer for the Synthesis of Densely Substituted Pyrazoles
126
Stable Nickel Oxidative Addition Complexes for the Versatile Elaboration of Bioactive Molecules
127
Facile Copper-Mediated α-(Hetero)arylation of Nitroalkanes
128
Formal Nitrogen Insertion for the Synthesis of Aza-Heterocycles
129
Robust Difluoromethylation of Aryl Halides
130
Synthesis of Triazole-Based Peptidomimetics

Synthesis of Materials and Unnatural Products

z131
All PDFs of this category
131
Synthesis and Trapping of an Anti-Bredt Olefin
132
A Perfluoroalkylating Reagent from Polyfluorinated Alcohols
133
1,4-Disilabenzenes: Low-Valent Silicon Aromaticity
134
Radical Homopolymerization of Thiocyanated α-Olefins
135
Topologically Chiral Interwoven Trimeric Cage-Catenanes
136
An Aromatic Molecular Pinwheel
137
Perfluorinated Nanographene
138
Quintuple Helicenes
139
Porous Nanocarbons
140
1,4-Azaborine-Embedded Helical Nanographene
141
One-Pot Synthesis of Chiral [6]Cyclonaphthylene
142
A Sterically Demanding Peropyrene

Metals in Synthesis

z143
All PDFs of this category
143
A Manganese-Catalyzed Knorr Pyrrole Synthesis
144
Cross-Electrophile Coupling via Iron-Mediated Tandem S-N2/SH2-Type Reaction
145
Palladium-Catalyzed Intramolecular Asymmetric Aminoacetoxylation of Internal Alkenes
146
Conversion of Enamides to Chiral 1,3-Amino Alcohols Using Rhodium Catalysis
147
Asymmetric 1,2-Dicarbofunctionalization of Vinyl Boronates under Dual Photoredox and Nickel Catalysis
148
Asymmetric Kinugasa/Aldol and Kinugasa/Mannich Reactions
149
Cooperative Rhodium/Guanidine–Sulfonamide Catalysis Enables Asymmetric Carbene Insertion into Se–S Bonds
150
Pd-Catalyzed Carbonylative Cyclization of Propargylic Ureas
151
Copper-Catalyzed Carbonyl-Assisted 1,4-Selective Aminohydroxylation of 1,3-Dienes
152
Imine-Directed C–H Activation Enables Expedient Access to Tetrahydroquinolines
153
Transfer Dihalogenation of Unsaturated Hydrocarbons under Iridium Photoredox Catalysis
154
Enantioselective Synthesis of Chiral Benzocyclobutanes via Palladium Catalysis
155
Access to Hindered Azoarenes by Denitrogenative Coupling of Aryl Azides Using a Dinickel Complex
156
Synthesis of Disubstituted Naphthalenes via Palladium [4+2] Annulation
157
Asymmetric Hydroamination of Styrenes with Organic Azides under Nickel Hydride Catalysis
158
Enantioselective Synthesis of Axially Chiral Macrocycles
159
Copper-Catalyzed Enantioselective 1,4-Borylamination of Arylidenecyclopropanes
160
Synthesis of 4-Substituted Indoles via Rhodium C–H Activation
161
Iron-Catalyzed Suzuki Cross-Coupling of (Hetero)Aryl Chlorides with Activated Aryl Boronic Esters
162
Palladium-Catalyzed Alkynylation of Unactivated Arenes
163
Iterative Catellani-Type C–H Functionalization of Aryl Ketone Oxime Ethers
164
Asymmetric Branched Allylation of Pyrazolones for the Synthesis of Quaternary Stereocenters
165
Rhodium-Catalyzed Three-Component Synthesis of β-Quaternary Amines
166
Stereoselective Synthesis of C-Glycosides Enabled by Iridium Photocatalysis
167
Palladium-Mediated Amine Differentiation to Access Unsymmetrical Chiral Diamines
168
The Transition-Metal-Catalyzed Buchner Reaction: Ring Expansion of Arenes to Cycloheptatrienes

Polymer-Supported Synthesis

z169
All PDFs of this category
169
Continuous-Flow Total Synthesis of (–)-Debromoflustramine B Using Homochiral Polymer-Supported Pd NPs
170
Preparation of a PS-Resin-Supported Triarylphosphonium Salt and Its Use in Sydnone Synthesis
171
Development of Polymeric Bis(triphenylphosphine)iminium Chloride as a Recyclable Catalyst
172
Benzylic/Allylic Borylation with an α-Fe2O3-Supported Nano Au Catalyst
173
Carbonylative Cyclization of 2-Iodofluorobenzenes with 2-Aminophenols by an SBA-Supported Pd Complex
174
Synthesis of Arylpyrazines from Acetophenones and 1,2-Diamines Using a Fe3O4-Supported CuO Catalyst
175
Photocatalytic Oxidation of Sulfides in Water Using a Donor–Acceptor-Based Porous Organic Polymer
176
C=O Selective Hydrogenation of α,β-Unsaturated Aldehydes Using B/N Co-Doped Carbon Materials
177
Cyclization of Alkynylanilines Promoted by In Situ Generated Gold(I) Nanoparticles in Micelles
178
Hydrogenation of Aldehydes and Ketones Using Single-Atom Copper in MOF-303
179
Controlled Hydrogenation of Terminal Alkynes Using Single-Atom Pd on B-Containing Amorphous Zeolite

Organo- and Biocatalysis

z181
All PDFs of this category
181
One Enzyme – Two Variants: Enantioselective Synthesis of Fused Lactones Giving Access to Two Enantiomers
182
Photocatalytic Single-Atom Editing for Direct Furan-to-Pyrrole Conversion
183
Photocatalyzed Synthesis of Carbon-Substituted Piperazines from Functionalized Diamines
184
Superbase-Catalyzed Concerted SNAr Reactions on Unbiased Arenes
185
Chiral Diol Catalyzed Asymmetric Synthesis of Allylic Hydrazides
186
Umpolung Birch Reduction of Naphthalenes
187
Organocatalytic Kinetic Resolution of Tertiary Pyrazolone Alcohols
188
Enzymatic Cascades Enable Biocatalytic Rearrangement of Furans toward Enantioenriched Spirolactones
189
Stereoselective Radical Acylfluoroalkylation of Bicyclobutanes via N-Heterocyclic Carbene Catalysis

Innovative Drug Discovery and Development

z191
All PDFs of this category
191
Spiro Cyclopropane Influences Axial Substituent Disposition in Cyclohexanes, Piperidines and Piperazines
192
One-Pot Homologation of Aliphatic Carboxylic Acids
193
Selective N-Alkylation of Pyridinium Ylides
194
Dynamic Kinetic Resolution Provides Anti-AIDS Drug
195
Ti(III)-Mediated Generation of Anomeric Radicals Turns Native Saccharides into Valuable C-Glycosides
196
Discovery of Clinical Candidate Rezatapopt, a Small-Molecule Reactivator of p53 Y220C Mutants
197
An Anticancer Codrug with a Biodegradable Core and an Enzyme Recognition Site
198
Access to Enantiomerically Enriched Oxazinanones from Olefins and In Situ Generated N-Boc-Formaldimine
199
Photo-Stereoprobes Reveal Undiscovered Stereoselective Ligand–Protein Interactions
200
Enantioselective Synthesis of Tetrahydro-β-Carbolines via Copper/Iridium Dual Catalysis
202
Enantioselective Cycloetherification of Hydroxy Ketones
203
Synthesis of Dispirocochlearoid A–C Derivatives
204
Structure–Activity Guided Macrocyclization of NLRP3 Inhibitors
205
Biocatalytic Reduction of a Hydrofuranone

Peptide Chemistry

z207
All PDFs of this category
207
Palladium-Catalyzed Late-Stage Macrocyclization for the Synthesis of Cyclophane-Braced Glycopeptides
208
Photoredox-Catalyzed Glycosylation at Dha in Peptide Sequences
209
PIFA-Mediated Enantioselective Synthesis of Azatricycles
210
Stereoselective Synthesis of P-Stereogenic ProTides Catalyzed by a Copper Catalyst
211
Synthesis of Chiral α-Amino Acid Derivatives via Chiral Photocatalyzed Deracemization of NCAs
212
Synthesis of Cyclopropyl-Ring-Containing Unnatural Amino Acid Derivatives
213
β-Amino Acid Synthesis via Aminocarbonylation
214
Stereoselective Synthesis of Amino Esters via 1,5-Conjugate Addition Using Pd/Cu Dual Catalysis
215
Site-Selective C(sp3)–H Alkenylation of Peptides by Palladium(II) Catalysis
216
Synthesis of cis-4-Hydroxy-L-Prolyl Amides Using a Telescoped One-Pot Methodology
217
Self-Assembled Peptide with Installed Au(I) Complexes as Effective Catalysts for Intramolecular Cyclization
218
Synthesis of 1,2,4-Oxadiazoles Bearing Chiral N-Protected α-Amino Acids

Flow Chemistry

z219
All PDFs of this category
219
Synthesis of γ- and ε-Lactams in Flow