DOI: 10.1055/s-00000131

Synfacts

Issue 12 · Volume 20 · December 2024 DOI: 10.1055/s-014-60584

Synform

A183
Zanda, Matteo: SYNFORM ISSUE 2024/12

Synthesis of Natural Products

z1233
All PDFs of this category
1233
Total Synthesis of (±)-Niduterpenoid B
1234
Total Synthesis of (±)-Erythrinine and Congeners
1235
Total Synthesis of (+)-Formicamycin H
1236
Chemoenzymatic Synthesis of (+)-Tetrandrine
1237
Total Synthesis of (–)-Flueggeacosine C
1238
Total Synthesis of (–)-Dithiosilvatin and (–)-Bilain A
1239
Total Synthesis of (–)-Tetracycline

Synthesis of Heterocycles

z1241
All PDFs of this category
1241
Biocatalytic, Enantioselective Synthesis of Lactams
1242
Synthesis of Difluoromethylpyrazoles from Difluoroacetohydrazonoyl Bromides and Nitriles
1243
Synthesis of Spiroketals via a Copper-Catalyzed [3+2] Annulation of Sulfonyl Enamides
1244
Simple, Regioselective Multicomponent Reaction to Achieve Pentacyclic Systems Based on Quinolines
1245
Substituted Imidazoles via Cobalt-Catalyzed Coupling of Enaminones with Oxadiazolones
1246
Tertiary Nitroalkanes through the Hydronitration of Olefins
1247
Stereocontrolled Syntheses of Bicyclic Diaza[3.3.0]octane Carboxylic Acids
1248
Direct Formation of CF2H Derivatives from Alcohols
1249
Mild SNAr-Approach to 2-Aminopyridines
1250
Modular Access to Functionalized 1,6-Naphthyridones
1251
Versatile Difunctionalization of Aryne Derivatives
1252
General Ether Synthesis through the Cross-Coupling of Alcohols with Olefins

Synthesis of Materials and Unnatural Products

z1253
All PDFs of this category
1253
Nonplanar Nanographene with 85 Fused Rings
1254
Radical–Radical C–C Coupling-Enabled [4]Rhombenes
1255
Four-Membered-Ring-Embedded Polycycloarene
1256
4,5-Fused Open-Shell Bis-Fluorenes
1257
Chacolgen-Containing Spiro-Buckybowls
1258
Helicenes with a BN Inner Rim
1259
Crystalline Triangular Triboron
1260
A BN-Benzvalene
1261
Trapping m-Benzyne
1262
Dicarbofunctionalized Cyclooctene Monomers
1263
Mechanically Gated Degradation of Polyethylenes
1264
Potassium-Ion- versus Palladium-Promoted Alkyne Cyclotrimerization

Metals in Synthesis

z1265
All PDFs of this category
1265
Copper-Catalyzed Cross-Nucleophile Alkylarylation of Vinylarenes with Two Different Boronic Acids
1266
Atroposelective Synthesis of Biheteroaryl Isoquinolines via Palladium Catalysis
1267
Photoredox-Catalyzed Radical Alkyl Transfer Using Recyclable Sulfoximines
1268
Synthesis of Biaryls via Nickel-Catalyzed Cross-Coupling
1269
Solvent-Controlled C(sp2)–H-Fluoroalkylation of (Hetero)Arenes with CF2Br2 under Photocatalysis
1270
Synthesis of Disubstituted Benzofulvenes via Palladium Catalysis
1271
Rearrangement of Vinylcyclobutanones to β,γ-Unsaturated Cyclohexanones
1272
Synthesis of Triarylated Enynes via Palladium Catalysis
1273
Primary Amination of C(sp3)–H Bonds Enabled by a Protonated Iron–Nitrene Complex
1274
Nickel-Catalyzed, Highly Selective, and Convergent Allylic Substitution of Allyl Chlorides with Phenols
1275
Regioselective Radical Hydrohalogenation and Hydroazidation of Alkenes through Iron Catalysis
1276
4+3 Reaction of 4-Hydroxymethylindoles and Aziridines Providing Azepinoindoles via Copper Catalysis
1277
Asymmetric Alkylarylation of Olefins with Alkanes and Aryl Halides via a Photoelectrocatalytic Approach
1278
Synthesis of α-Amino Acids via a Pd(II) C–H Activation/Desymmetrization of Amino Carboxylic Acids
1279
Copper-Catalyzed Asymmetric Sulfur-Arylation of Sulfenamides via Chan–Lam-Type Coupling
1280
Asymmetric Heterodimerization of Enamides and Olefins via Nickel Catalysis
1281
Palladium-Catalyzed Asymmetric β,γ-Dehydrogenation of Cycloalkyl Amides to Access Chiral Carbocycles
1282
Regiodivergent Asymmetric Synthesis of 1,2- and 1,3-Amino Alcohols from Allylamines
1283
Nickel-Catalyzed Decarbonylative C(sp3)–C(sp3) Cross-Electrophile Coupling
1284
Copper-Catalyzed Synthesis of Unsymmetrical Diaryl Sulfides Using an Odorless Sulfur Source
1285
A Protolysis Approach Enables Samarium-Catalyzed Reductive Cross-Coupling of Ketones and Acrylates
1286
Metallophotoredox-Enabled Z-Selective Hydroalkylation of Alkynes and Tandem Z–E Inversion
1287
Selective Hydro- and Carbocyanation of Alkynes via Photoexcited Nickel Catalysis
1288
Reductive Desymmetrization of Malononitriles Enabled by Cobalt Catalysis
1289
Asymmetric Cross Coupling of Racemic H-Phosphinamides with Aryl and Vinyl Bromides
1290
A Carbonylative Narasaka–Heck Cyclization: Aminoacylation of Unsaturated Oxime Esters

Polymer-Supported Synthesis

z1291
All PDFs of this category
1291
Single-Atom Zinc-Catalyzed C/N-Alkylation through Borrowing Hydrogen Processes
1292
Photocatalytic Oxidative Condensation of Benzyl Alcohols and Anilines with MIL-53(Fe) MOF
1293
Photocatalytic S–N Coupling of Thiols and Amines by K-Doped Copolymers of Triaminoheteroarenes
1294
C–H Activation Using a CdS Quantum Dots Gel as a Hydrogen-Atom-Transfer Photocatalyst
1295
Nano-Cobalt-Catalyzed Reductive Amination of Aldehydes and Ketones with NH3 and H2
1296
Photocatalytic Oxidative Dimerization of Amines with Borotungstate Polyoxometalates Bearing P, As, or Si
1297
Enantioselective 1,4-Reduction of Conjugated Aldehydes by Carbon Dots and Chiral Phosphoric Acids
1298
Polymer-Supported nano Pd-Catalyzed Hydrogenolysis of O- and N-Benzyl Groups in Water with B2(OH)4
1299
Pd/Cu Supported on Defective MOFs for Oxidative Aminoamidation of N-Sulfonyl-2-Allylanilines
1300
Acceptorless Dehydrogenative Coupling for the Synthesis of Quinolines Using a Single-Atom Fe Catalyst
1301
Reductive Amination of Carbonyl Compounds with Amines or Ammonia Using a Single-Atom Iron Catalyst

Organo- and Biocatalysis

z1303
All PDFs of this category
1303
Direct Asymmetric Functionalization of α‑Amino C–H Bonds
1304
Non-Natural Photodecarboxylase Enables Stereospecific Radical Coupling of Enals and Carboxylic Acids
1305
Efficient Hydrogen Evolution Reaction Catalyzed by an N-Heterocyclic Phosphine
1306
Chiral Phosphoric Acid Catalyzed Enamine C-Acylation for the Synthesis of Pyrrolinones and Indolinones
1307
Access to Enantiopure 2-Azabicyclo[3.1.1]heptane Derivatives via Lewis Acid Catalysis
1308
Pyridine Synthesis via Unprecedented 6-endo-Cyclization of Cyclopropylamides with Alkynes
1309
Chiral Lewis Base Catalyst Enables Asymmetric Multicomponent 1,2-Boronate Rearrangement
1310
Stereoselective Tandem Biocatalytic Reaction to Access Saturated N-Heterocycles
1311
Aldehyde–Olefin Couplings via Sulfoxylate-Mediated Oxidative Generation of Ketyl Radical Anions
1312
Enzymatic α-Amination of Alkylcarboxylic Acid Esters

Innovative Drug Discovery and Development

z1313
All PDFs of this category
1313
Cleavable Linker Delivers Increased Solubility of Highly Insoluble Small-Molecule Therapeutics
1314
Displacement of a Water Molecule Enhances Drug Residence Time
1315
A Scalable and Sustainable Transition-Metal-Free Stereoretentive Decarboxylative Amidation
1316
Chiral β-Branched Amines via Enzymatic Asymmetric Reductive Amination
1317
Pulling the Brake on Neuromuscular Blocking Agents: New Host Molecule as Potential Universal Antagonist
1318
Oxadiazolines as Tools for Photoaffinity Labeling
1319
Preparing Trifluoromethyl Analogues with Boronic Acids and Rhodium
1320
Csp3–H Functionalization of Sugar Derivatives
1321
Hydroxyaryl-Tetrazines Enable Fast and Efficient Biorthogonal Click-to-Release
1322
Fragment Coupling Approach Enables Expedient Access to Bioactive Norcembranoid Natural Products
1323
Immunosuppressive Macrocycles Accessed through a Fragment Coupling Approach
1324
Identification of New Leads for the Indazole-Based LRRK2 Inhibitors
1325
Aldol Cyclization with a Twist: Asymmetric Approach Yields CF3-Functionalized Heterospirocycles
1326
Development of Catalyst Differentiation Strategy to Synthesize Amines
1327
Synthesis of Multitarget Ligands for Alzheimer’s Disease

Peptide Chemistry

z1329
All PDFs of this category
1329
Peptide Synthesis Using Unprotected Amino Acids
1330
Late-Stage Functionalization for the Introduction of Sulfilimines into Peptides
1331
Photoredox Catalysis for Site-Selective Aklylation of Glycine and Glycine-Containing Peptides
1332
Iridium-Catalyzed Photoredox Functionalization of Glycine Derivatives
1333
Enantioselective Synthesis of Unnatural α-Amino Acids Using Catalytic Addition of Thiol
1334
Photochemical Strategy for Radical Pathway to Access β -Amino Acid Derivatives
1335
Cyclic Tetrapeptide Synthesis via an Epimerization-Free Direct Aminolysis
1336
Total Synthesis of Cyclic Hexapeptides: Nicrophorusamides A and B
1337
Direct C–H Alkylation of Glycine Derivatives with Alkenes by Radical-Polar Crossover Reaction
1338
Cyclization of N-Propargyl-N-Sulfonyl Amino Alcohols by Silver Catalysis and Solid-Phase Applications
1339
Accessing Macrocyclic Thiolactone Peptides by Radical-Mediated Intramolecular Thiol–Ene Ligation
1340
Asymmetric N-Allylation of Amino Acids and Peptides
1341
Cobalt-Catalyzed Reductive Addition of Dehydroglycine
1342
Alkylation of Glycine Derivatives via a Combination of Single-Electron and Halogen-Atom Transfers
1343
Stereoselective Michael Addition Reaction for Synthesis of Unnatural Amino Acids

Flow Chemistry

z1345
All PDFs of this category
1345
Flowing towards β-Silyl Amines via Energy Transfer and Hydrogen Atom Transfer

Erratum

1346
Oestreich, Martin; Klare, Hendrik F. T.; Pommerening, Phillip: Erratum: Regioselective Three-Component Carboamination of Propargylic Alcohols to Access N,O-Heterocycles