DOI: 10.1055/s-00000131

Synfacts

Issue 01 · Volume 21 · January 2025 · Sample Issue DOI: 10.1055/s-014-60771

Synthesis of Natural Products

z1
All PDFs of this category
1
Total Synthesis of (+)-Garajonone
2
Synthesis of (–)-Bipolarolide D
3
Synthesis of (±)-Berkeleyone A and (±)-Preaustinoid A
4
Total Syntheses of (–)-β- and (–)-γ-Naphthocyclinones
5
Total Synthesis of (+)-Cylindricine C
6
Formal Synthesis of (±)-Morphine
7
Total Synthesis of (+)-Pumiliotoxin A

Synthesis of Heterocycles

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All PDFs of this category
9
Facile Synthesis of Pyridones from Cyclopentenones
10
Photochemical Pathway for Synthesis of 2- or 3-Cyanoindoles and Mechanistic Insights
11
Synthesis of Tetrahydroquinolines from Arylaminomenthyl Cyclopropanes
12
Photoenyzmatic Reductive Coupling of Electron-Deficient Heterocycles with Alkenes
13
Enzymatic Synthesis of Pyrrolines/Indolines
14
Diastereoselective Synthesis of Densely Functionalized 1-Pyrrolines
15
Strain-Release of Azetidines for the Synthesis of 3,4,5-Trisubstituted Piperidines
16
Diversity-Oriented Synthesis of Macrocycles
17
Rational Catalyst Design for an Optimized Aza-Michael Addition
18
Modular Access to Oxymorphinan Derivatives

Synthesis of Materials and Unnatural Products

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All PDFs of this category
19
Click-Clip
20
Controlling 1,4-Palladium Aryl to Aryl Migration
21
A Catenate Interlocked 2D Covalent Organic Framework
22
γ-Graphynes from SNAr Reactions
23
A New Luminescent Dicarbazolyl Methyl Radical
24
A Pentacene Tetraimide
25
Thiahelicenes into Coronenes
26
Highly Twisted Fenestrindanes
27
Weaving Molecules
28
BN3-Bridged D-π-A Molecules with Narrow-Band Near-Infrared Emissions
29
Large Dibora-Polycyclic Aromatic Hydrocarbons from Alkyne Annulation
30
Seleno- and Telluroesters from Photoreactions of Acylsilanes

Metals in Synthesis

z31
All PDFs of this category
31
Amidyl Radical Insertion to Bicyclo[1.1.0]butanes Using Photocatalysis
32
Palladium-Catalyzed Formamidation of Aryl Halides Using Sodium Azide and Oxalic Acid
33
Remote Alkylation of Alkenes via an Iridium-Mediated Chain-Walking and Carbene Insertion Cascade
34
Synthesis of 1-Indanones by Photoredox-Catalyzed (3+2) Annulation of Aromatic Amides with Olefins
35
Iridium-Catalyzed Anti-Markovnikov Hydrocarboxylation of Olefins
36
Propargylic C(sp3)–H Etherification via an Allenyl–Iron Organometallic Species
37
Asymmetric Addition of Organozinc Reagents to Aldehydes
38
Asymmetric Semipinacol Rearrangement of Diarylallylic Alcohols to α-Aryl Ketones under Cobalt Catalysis
39
Dual-Metal-Catalyzed Synthesis of Fused Quinolin-2(1H)-one Scaffolds
40
Nickel Hydride Catalyzed Enantioselective Synthesis of Alkenyl Cyclobutanols from 1,4-Alkynones
41
Palladium-Catalyzed Synthesis of Homoallylic Alcohols via an Umpolung Hydrazone Strategy
42
Photoredox-Catalyzed Hydronitration and Hydronitroalkylation of Alkenes
43
Indazole Synthesis through the Copper-Catalyzed Cyclization of 2-Alkynylazobenzenes
44
Asymmetric Allylic C(sp3)–H Acyloxylation of Internal Alkenes Enabled by Photoexcited Copper Catalysis
45
Access to Non-canonical Tryptophan Derivatives by Rhodium-Catalyzed C–H Functionalization of Anilines
46
Nickel-Catalyzed Enantioselective Decarboxylative Difluoromethylation of Phthalimide Esters
47
Palladium-Catalyzed Synthesis of Cyclic Boronates from Vicinal-diboronates and 2-Halophenols and Anilines
48
Reductive Ring Opening of N-Benzoyl Pyrrolidines under Lewis Acid Assisted Photoredox Catalysis
49
Shuttle Catalysis Enabled by Cobalt Hydrides: Efficient Hydrofunctionalization of Terminal Alkenes
50
Nickel-Catalyzed Tertiary C(sp3)–H Bond Methylation Enabled by Photochemically Activated Alkyl Peroxides
51
Dehydrogenation of Apolar Amino Acids to Access Versatile Non-Canonical Amino Acids
52
Photoredox-Catalyzed Direct Olefination of Carboxylic Acids with Phenyl Vinyl Ketones
53
Asymmetric Synthesis of α-Amino Nitriles from Carboxylic Acids
54
A New Class of Pyridine-Derived NHCs Enables Copper-Catalyzed Asymmetric Allylic Alkylation
55
The Heck Carbonylation: Palladium-Catalyzed Alkoxycarbonylation of Organic Halides
56
Copper-Accelerated Palladium-Catalyzed Cross-Coupling of Terminal Alkynes and sp2 C–X Bonds

Polymer-Supported Synthesis

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All PDFs of this category
57
Photoelectrochemical Alkene Epoxidation with Water Using a TiO2-Ru Anode
58
Montmorillonite-Catalyzed Construction of Hantzsch Derivatives Using UHP under Microwave Irradiation
59
Alkylidene Bisamide Condensation with a Graphene Oxide Based Hydrogen Sulfate Nanocomposite
60
LDH-Supported Nano Cu(I)-Catalyzed Multicomponent Reaction Forming Benzopyrans
61
Dehydrogenative Annulation of 3-Amino Alcohols with Secondary Alcohols by Cobalt Nanoparticles
62
Photocatalytic Cycloaddition and Oxidation by a Benzothiadiazole-Based Ordered Mesoporous Polymer
63
Photocatalytic Synthesis of 2-Hydroxybenzofuran-3(2H)-ones Using Double Perovskite Cs2AgBiBr6 Nanocrystals
64
Markovnikov Selective Hydroamination of Vinylarenes with Aromatic Amides Using Hβ Zeolite
65
Nitrogen-Doped Carbon-Encapsulated Ni Nanoparticles for Selective Hydrogenation of Nitroarenes
66
Oxidative Amidation of Alcohols Using Lead-Free Metal Halide Perovskite
67
Photoinduced Oxidation of Sulfides Using Donor–Acceptor Heterojunction Fiber-Like Micelles

Organo- and Biocatalysis

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All PDFs of this category
69
Electrochemical Organocatalytic Production of Methane
70
Transaldolases Enable Asymmetric Aldol Addition to Unactivated Ketones
71
Asymmetric Synthesis of Chiral α,α-Dialkyl Amines
72
Enantioselective Hydrogen Atom Abstraction Catalysis
73
Photocatalytic Carboxylation of Benzylic Tertiary C−H Bonds with CO2 in the Presence of Stoichiometric Base
74
Catalytic Asymmetric Cracking of Cyclopropanes
75
Brønsted Acid–HFIP Combination Allows Amination of 2-Arylethanols via Phenonium Intermediate
76
Sustainable Silane Oxidation to Silanols via Frustrated Lewis Pair Catalysis with Water
77
Photocatalytic Functionalization of Weakly Nucleophilic Alkenes with Electrophiles
78
Formal [3+2] Cycloaddition Catalyzed by Lewis Base: A Straightforward Route to 1,3-Dioxolane Derivatives

Innovative Drug Discovery and Development

z79
All PDFs of this category
79
Gatekeeper Pocket as Auxiliary Interaction Site for Macrocyclic Cyclophilin Inhibitors
80
Radiosynthesis of [18F]Trifluoroiodomethane and Its Use for Radical 18F-Trifluoromethylation Reactions
81
Synthesis of Enantiopure Piperidines on Industrial Scale
82
Convenient Synthetic Access to 1,5-Disubstituted 2‑Oxabicyclo[2.1.1]hexanes as ortho-Substituted Benzene Mimics
83
Enantioselective, Catalytic HFL Reaction to Access Chiral 2,5-Pyrrolidines
84
A Two-Step Approach to Functionalized Aziridines
85
A Photoswitchable Analogue of the GABAA Agonist-Potentiator Abecarnil
86
Multigram-Scale Macrobicyclic Thiolincosamine Synthesis
87
New Procedure for On-DNA Diazo-Transfer
88
Shedding Some New Light on 1,2-Dicarbonyl Deoxygenations
89
Umpoled Approach to Silicon Glycomimetics
90
Generation of Tertiary Alkylamines by Photoredox Catalysis and Nickel-Catalyzed Cross-Coupling
91
Photoswitchable Negative Allosteric Modulator of GluN2B-Containing NMDA Receptors
92
SAR Analysis Delivers Promising Piezo1 Channel Agonist
93
Metal-Free Deuteration of Arenes with D2O Enabling Late-Stage Functionalization

Peptide Chemistry

z95
All PDFs of this category
95
Electrochemical Ring-Opening Reaction of Piperidine-Containing Peptides
96
Palladium-Catalyzed Late-Stage Functionalization for Installation of Maleimide Scaffolds into Peptides
97
Flavin-Catalyzed Synthesis of 4,5-Dihydroxynorvaline
98
BODNs as New Reagents for Visible-Light Photocatalytic Bromination of Tyrosine Residue
99
Synthesis of (2S,3R,4R)-Dihydroxyisoleucine (DHIle) and Its Application in Amatoxin Synthesis
100
Asymmetric Synthesis of β3-Tryptophan via C–H Amination
101
Pd-Catalyzed Synthesis of Thioglycopeptide
102
Synthesis of Diketopiperazines from α-Amino Amides and Diazophosphonate Ester Using Cp*Rh(III) Catalyst
103
Synthesis of Unnatural Amino Acids and Peptides via Desulfurative Alkylation of Cysteine Derivatives
104
Advanced Thiol Nucleophiles and Peptide Hydrazides in the Synthesis of Peptide Alkyl Thioesters
105
N-Terminal Thiazolidine-Containing Peptide Thioesters via a Thioproline-Based Oxidation Approach
106
1,2-Phospha-Brook Rearrangement for Synthesis of Phosphorylated Tyrosine Derived Peptides
107
Ethyl Propiolate Mediated Peptide Synthesis

Flow Chemistry

z109
All PDFs of this category
109
Avoiding PFAS in the Preparation of Functionalized Trifluoromethylated Heteroatoms