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Synfacts 2009(1): 0058-0058
DOI: 10.1055/s-0028-1087431
DOI: 10.1055/s-0028-1087431
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Nickel-Catalyzed Coupling of Alkynes and Aldehydes
Y. Yang, S.-F. Zhu, C.-Y. Zhou, Q.-L. Zhou*
Nankai University, Tianjin, P. R. of China
Further Information
Publication History
Publication Date:
18 December 2008 (online)
Significance
Alkylative coupling of alkynes and aldehydes in the presence of an organoalkane provides access to allylic hydroxy tetrasubstituted olefins. The authors report the first enantioselective version of this reaction with aldehydes, although imines are known (see: S. J. Patel, T. F. Jamison Angew. Chem. Int. Ed. 2003, 42, 1364; S. J. Patel, T. F. Jamison Angew. Chem. Int. Ed. 2004, 43, 3941).