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Synlett 2009(3): 390-394
DOI: 10.1055/s-0028-1087550
DOI: 10.1055/s-0028-1087550
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Organocatalytic Synthesis of an Alkyltetrahydropyran
Further Information
Received
2 September 2008
Publication Date:
21 January 2009 (online)
Publication History
Publication Date:
21 January 2009 (online)
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Abstract
The first synthesis of an alkyltetrahydropyran using a diarylprolinol organocatalyst is described.
Keywords
organocatalysis - tetrahydropyrans - diarylprolinol - cyclization
- Supporting Information for this article is available online:
- Supporting Information
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References and Notes
When reductions were performed with NaBH4, MeOH was added as cosolvent.
30A racemic mixture of compound 16 was obtained by iodine cyclization of compound 13 and subsequent NaBH4 reduction of the iodo derivatives obtained.
32See the Supporting Information available.