Synthesis 2009(6): 909-912  
DOI: 10.1055/s-0028-1087979
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthetic Routes to Aminotriamantanes, Topological Analogues of the Neuroprotector Memantine®

Andrey A. Fokin*a,b, Anika Merzb, Natalie A. Fokinab, Hartmut Schwertfegerb, Shenggao L. Liuc, Jeremy E. P. Dahlc, Robert K. M. Carlsonc, Peter R. Schreiner*b
a Department of Organic Chemistry, Kiev Polytechnic Institute, pr. Pobedy 37, 03056 Kiev, Ukraine
b Institute of Organic Chemistry, Justus-Liebig University, Heinrich-Buff-Ring 58, 35392 Giessen, Germany
c MolecularDiamond Technologies, Chevron Technology Ventures, 100 Chevron Way, Richmond, CA 94802, USA
Fax: +49(641)9934309; e-Mail: aaf@xtf.ntu-kpi.kiev.ua; e-Mail: prs@org.chemie.uni-giessen.de;
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Publikationsverlauf

Received 22 September 2008
Publikationsdatum:
02. März 2009 (online)

Abstract

The amino derivatives of diamantane and triamantane, representing close topological analogues of the neuroprotective drug Memantine®, were prepared via amination of the respective carboxylic acids or alcohols.

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The structures have been deposited in the Cambridge Crystallographic Data Centre and can be retrieved using the following numbers: CCDC 701883 (14) and 701884 (16).