Preparation of 9-Substituted Pyridine-Stretched Adenines and Hypoxanthines

Abstract

9-Methylsulfanyl pyridine-stretched adenine and hypo­xanthine derivatives have been prepared via regioselective reaction of a 5-aminoimidazole with 2-(bis-methylsulfanylmethylene)malononitrile [(NC)₂C=C(SMe)₂]. The 9-methylsulfanyl substituent can be replaced by sequential oxidation and substitution by nucleophiles including amines.

Key words

5-aminoimidazoles - lin-pyridoadenines - soft electrophiles - tricyclic heterocycles - pyridine-stretched purines

References

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Clayton, R.; Davis, M. L.; Fraser, W.; Ramsden, C. A. manuscript in preparation.