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DOI: 10.1055/s-0028-1088359
© Georg Thieme Verlag KG Stuttgart · New York
Two New Adjacent Bis-Tetrahydrofuran Annonaceous Acetogenins from Seeds of Annona cornifolia
Publication History
Received: April 9, 2008
Revised: September 5, 2008
Accepted: September 10, 2008
Publication Date:
27 November 2008 (online)
![](https://www.thieme-connect.de/media/plantamedica/200901/lookinside/thumbnails/10.1055-s-0028-1088359-1.jpg)
Abstract
Two new adjacent bis-THF annonaceous acetogenins, 9-hydroxyfolianin (1) and folianin B (2), together with two known acetogenins, asimicin (3) and bullatacin (4), significantly bioactives in brine shrimp lethality test, were isolated from seeds of Annona cornifolia A. St. Hil (Annonaceae). Their structures were elucidated by NMR and ESI-MS analysis, and relative configurations were established. The absolute configuration around the THF rings of 1 was defined by Mosher esters methodology and circular dichroism.
Key words
Annona cornifolia A. St. Hil - Annonaceae - acetogenins - Cotton effect - Mosher ester derivatives
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Prof. Dr. Maria Amélia Diamantino Boaventura
Departamento de Química
Instituto de Ciências Exatas
Universidade Federal de Minas Gerais
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Brazil
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