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Horm Metab Res 1979; 11(3): 222-227
DOI: 10.1055/s-0028-1092713
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© Georg Thieme Verlag KG Stuttgart · New York

Postnatal Maturation Patterns of Serum Corticosterone and Growth Hormone in Rats: Effect of Chronic Thyroxine Administration

R. E. Poland , M. E. Weichsel Jr. , R. T. Rubin
  • Departments of Psychiatry and Pediatrics U.C.L.A. School of Medicine, Harbor General Hospital Campus, Torrance, California, U.S.A.
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Publikationsdatum:
17. Dezember 2008 (online)

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Abstract

The effects of chronic neonatal hyperthyroidism in rats on the ontogenic pattern of serum corticosterone and growth hormone (GH) were studied. Thyroxine (T4) treated and saline injected rat pups were sacrificed under basal and stress conditions. In comparison to saline control animals', daily T4 administration (0.4 µg/gram body weight) produced a sustained elevation in basal corticosterone levels by day 12 and a significant elevation of serum corticosterone in response to stress by day 4. The serum GH levels in non-stressed animals were moderately decreased in response to T4 administration as compared to saline injected animals with a greater reduction in GH measured in samples obtained from stressed animals. The results indicate that chronic T4 administration influences the developmental pattern of serum corticosterone and GH under both non-stress and stress conditions.

Key words

Development - Hyperthyroidism - Thyroxine - Corticosterone - Growth Hormone - Rats