PDF herunterladen
Horm Metab Res 1973; 5(1): 26-28
DOI: 10.1055/s-0028-1093996
Originals

© Georg Thieme Verlag KG Stuttgart · New York

The Effect of L-Dopa on Insulin Release by Isolated Pancreatic Islets of the Rat[*]

A. A. Rossini [**] , M. G. Buse
  • Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, U.S.A.
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
07. Januar 2009 (online)

Auch verfügbar auf
  als PDF herunterladen  Lizenzen und Reprints

Abstract

Isolated islets of Langerhans of the rat were incubated for one hour in the presence of 16 mM glucose. The effect of L-dopa, α-methyl-L-dopa and L-tyrosine on insulin release was studied. L-dopa (2.5 x 10-5M) and α-methyl-L-dopa (10-4 M) each significantly inhibited insulin release. At this dose, the combination of the two compounds was significantly more inhibitory than either compound alone. L-tyrosine (10-4 M) did not affect insulin secretion.

Key words

Islets of Langerhans - Insulin Secretion - L-Dopa - α-Methyl-L-Dopa - L-Tyrosine

1 This study was supported by U.S.P.H.S. Grants AM-05078 and AM-02001, National Institute of Arthritis and Metabolic Diseases

1 This study was supported by U.S.P.H.S. Grants AM-05078 and AM-02001, National Institute of Arthritis and Metabolic Diseases

2 Past address: LCDR A.A. Rossini, MC, USNR, Charleston Naval Hospital, Charleston, South Carolina, U.S.A.
Present address: Elliott P. Joslin Research Laboratory, Harvard Medical School, Boston, Mass., U.S.A.

3 APUD = amine precursor uptake-decarboxylation