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Horm Metab Res 1973; 5(1): 26-28
DOI: 10.1055/s-0028-1093996
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© Georg Thieme Verlag KG Stuttgart · New York

The Effect of L-Dopa on Insulin Release by Isolated Pancreatic Islets of the Rat[*]

A. A. Rossini [**] , M. G. Buse
  • Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, U.S.A.
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

Isolated islets of Langerhans of the rat were incubated for one hour in the presence of 16 mM glucose. The effect of L-dopa, α-methyl-L-dopa and L-tyrosine on insulin release was studied. L-dopa (2.5 x 10-5M) and α-methyl-L-dopa (10-4 M) each significantly inhibited insulin release. At this dose, the combination of the two compounds was significantly more inhibitory than either compound alone. L-tyrosine (10-4 M) did not affect insulin secretion.

Key words

Islets of Langerhans - Insulin Secretion - L-Dopa - α-Methyl-L-Dopa - L-Tyrosine

1 This study was supported by U.S.P.H.S. Grants AM-05078 and AM-02001, National Institute of Arthritis and Metabolic Diseases

1 This study was supported by U.S.P.H.S. Grants AM-05078 and AM-02001, National Institute of Arthritis and Metabolic Diseases

2 Past address: LCDR A.A. Rossini, MC, USNR, Charleston Naval Hospital, Charleston, South Carolina, U.S.A.
Present address: Elliott P. Joslin Research Laboratory, Harvard Medical School, Boston, Mass., U.S.A.

3 APUD = amine precursor uptake-decarboxylation