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Planta Med 1978; 34(7): 287-290
DOI: 10.1055/s-0028-1097452
Research Articles

© Georg Thieme Verlag Stuttgart · New York

The Effects of Saikosaponins on Biological Membranes

2. Changes in Electron Spin Resonance Spectra from Spin–Labelled Erythrocyte and Erythrocyte Ghost MembranesHiroko Abe1 , Shizuo Odashima2 , Shigeru Arichi1
  • 1The Research Institute of Oriental Medicine, Kinki University School of Medicine, Sayama–cho, Minami–kawachi–gun, Osaka, Japan.
  • 2Department of Pathology, Kanazawa Medical University, Uchinadamachi, Ishikawa, Japan,
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Publication History

Publication Date:
13 January 2009 (online)

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Abstract

The effects of saikosaponins a, b 1, b2, c and d, isolated from the root of Bupleurum falcatum L., on membrane fluidity using spin–labelled erythroeytes were examined. Saikosaponins a and b2 in which the C–16 OH of epoxyoleanene skeleton is in β position caused the remarkable decrease of membrane fluidity but saikosaponin d and b2 in which the 16 OH is in a position showed weaker actions on membrane fluidity.

Key Word Index

Bupleurum falcatum L - Saikosaponin - Spin–label - Membrane fluidity