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Klin Monbl Augenheilkd 2009; 226(4): 220-223
DOI: 10.1055/s-0028-1109287
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Aktueller Stand der Entwicklung und Anwendung von Farb- und Markierungsstoffen für die vitreoretinale Chirurgie

Present State of the Development and Clinical Use of Dyes and Staining Substances for Vitreoretinal SurgeryH. Gerding1, 2
  • 1Abteilung für Retinologie, Klinik Pallas, Olten, Schweiz
  • 2AG Retina Implant, Universität Münster, Münster, Deutschland
Further Information

Publication History

Eingegangen: 26.9.2008

Angenommen: 13.11.2008

Publication Date:
21 April 2009 (online)

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Zusammenfassung

Die Markierung von Gewebestrukturen im hinteren Augensegment hat sich in den vergangenen 8 Jahren zu einem etablierten Bestandteil der vitreoretinalen Chirurgie entwickelt. In dieser Zusammenfassung wird ein Überblick über derzeitig verfügbare Markierungs- und Farbstoffe sowie deren operative Anwendung vermittelt.

Abstract

Staining of intraocular tissue has become an established tool of vitreoretinal procedures within the last 8 years. This review describes the presently available dyes and markers and their use during vitreoretinal procedures.

Schlüsselwörter

Vitalfarbstoffe - Brilliant Blue G - Indocyaningrün - Trypan Blau - Patent Blau - Retina - Vitrektomie - Lamina limitans interna

Key words

vital dyes - brilliant blue G - indocyanin green - trypan blue - patent blue - retina - vitrectomy - internal limiting membrane

Literatur

  • 1 Abrams G W, Topping T, Machemer R. An improved method for practice vitrectomy.  Arch Ophthalmol. 1978;  96 521-525
    Search in Google Scholar
  • 2 Ando F, Sasano K, Ohba N. et al . Anatomic and visual outcomes after indocyanine green-assisted peeling of the internal limiting membrane in idiopathic macula hole surgery.  Am J Ophthalmol. 2004;  137 744-746
    Search in Google Scholar
  • 3 Burk S E, da Mata A P, Snyder M E. et al . Indocyanine green-assisted peeling of the retinal internal limiting membrane.  Ophthalmology. 2000;  107 2010-2014
    Search in Google Scholar
  • 4 Burk S E, Da Mata A P, Snyder M E. et al . Visualizing vitreous using Kenalog suspension.  J Cataract Refract Surg. 2003;  29 645-651
    Search in Google Scholar
  • 5 Cevera E, Diaz Llopis M, Salom D. et al . Internal limiting membrane staining using intravitreal brilliant blue G: good help for vitreo-retinal surgeon in training.  Arch Soc Esp Oftalmol. 2007;  82 71-72
    Search in Google Scholar
  • 6 Doi N, Uemura A, Nakao K. et al . Vitreomacular adhesion and the defect in posterior vitreous cortex visualized by triamcinolone-assisted vitrectomy.  Retina. 2005;  25 742-745
    Search in Google Scholar
  • 7 Enaida H, Hiatomi T, Goto Y. et al . Preclinical investigation of internal limiting membrane staining and peeling using intravitreal brilliant blue G.  Retina. 2006;  26 623-630
    Search in Google Scholar
  • 8 Enaida H, Hisatomi T, Hata Y. et al . Brilliant Blue G selectively stains the internal limiting membrane/Brilliant Blue G-assisted membrane peeling.  Retina. 2006;  26 631-636
    Search in Google Scholar
  • 9 Engel E, Schraml R, Maisch T. et al . Light-induced decomposition of indocyanine green.  Invest Ophthalmol Vis Sci. 2008;  49 1777-1783
    Search in Google Scholar
  • 10 Gandorfer A, Haritoglou C, Gass C A. et al . Indocyanin green-assisted peeling of the internal limiting membrane may cause retinal damage.  Am J Ophthalmol. 2001;  132 431-433
    Search in Google Scholar
  • 11 Gass C A, Haritoglou C, Schaumberger M. et al . Functional outcome of macular hole surgery with and without indocyanine green-assisted peeling of the internal limiting membrane.  Graefes Arch Clin Exp Ophthalmol. 2003;  24 716-720
    Search in Google Scholar
  • 12 Guo S, Tuela A C, Wagner R. et al . A comparison of the effectiveness of four biostains in enhancing visualization of the vitreous.  J Pediatr Ophthalmol Strabismus. 2006;  43 281-284
    Search in Google Scholar
  • 13 Haritoglu C, Gandorfer A, Gass C A. et al . The effect of indocyanine-green on functional outcome of macular pucker surgery.  Am J Ophthamol. 2003;  135 328-337
    Search in Google Scholar
  • 14 Haritoglu C, Yu A, Freyer W. et al . An evaluation of novel vital dyes for intraocular surgery.  Invest Ophthalmol Vis Sci. 2005;  46 3315-3322
    Search in Google Scholar
  • 15 Haritoglu C, Tadayoni R, May C A. et al . Short-term in vivo evaluation of novel vital dys for intraocular surgery.  Retina. 2006;  26 673-678
    Search in Google Scholar
  • 16 Haritoglu C, Schumann R G, Strauss R. et al . Vitreoretinal surgery using bromphenol blue as a vital stain: evaluation of staining characteristics in humans.  Br J Ophthalmol. 2007;  91 1125-1128
    Search in Google Scholar
  • 17 Hasler P W, Prünte C. Early foveal recovery after macular hole surgery.  Br J Ophthalmol. 2008;  92 645-649
    Search in Google Scholar
  • 18 Hata Y, Enaida H, Sassa Y. et al . Preclinical investigation of fluorometholone acetate as a potential new adjuvant during vitreous surgery.  Graefes Arch Clin Exp Ophthalmol. 2007;  245 1019-1025
    Search in Google Scholar
  • 19 Hiebl W, Günther B, Meinert H. Substanzen zur Anfärbung von biologischem Gewebe – Farbstoffe in der Augenheilkunde.  Klin Mbl Augenheilkd. 2005;  222 309-311
    Search in Google Scholar
  • 20 Hillenkamp J, Saikia P, Herrmann W A. et al . Surgical removal of idiopathic epiretinal membrane with or without the assistance of indocyanine green: a randomised controlled clinical trial.  Graefes Arch Clin Exp Ophthalmol. 2007;  245 973-979
    Search in Google Scholar
  • 21 Iriyama A, Uchida S, Yanagi Y. et al . Effects of indocyanine green on retinal ganglion cells.  Invest Ophthalmol Vis Sci. 2004;  45 943-947
    Search in Google Scholar
  • 22 Jackson T L, Hillenkamp J, Knight B C. et al . Safety testing of indocyanin green and trypan blue using retinal pigment epithelium and glial cell cultures.  Invest Ophthalmol Vis Sci. 2004;  45 2778-2785
    Search in Google Scholar
  • 23 Jackson T L, Griffin L, Vote B. et al . An experimental method for testing novel retinal vital stains.  Exp Eye Res. 2005;  81 446-454
    Search in Google Scholar
  • 24 Jin Y, Uchida S, Yanagi Y. et al . Neurotoxic effects of trypan blue on rat retinal ganglion cells.  Exp Eye Res. 2005;  81 395-400
    Search in Google Scholar
  • 25 Jonas J B, Kreissig I, Degenring R. Intravitreal triamcinolone acetonide for treatment of intraocular proliferative, exsudative, and neovascular diseases.  Prog Retina Eye Res. 2005;  24 587-611
    Search in Google Scholar
  • 26 Kunikata H, Abe T, Sagara Y. et al . Hypthermia of 8 °C protects cultured retinal pigment epithelial cells and retinal ganglion cells against trypan blue toxcicity.  Am J Ophthalmol. 2006;  141 754-756
    Search in Google Scholar
  • 27 Lochhead J, Jones E, Chui D. et al . Outcome of ICG-assisted ILM peel in macular hole surgery.  Eye. 2004;  18 804-808
    Search in Google Scholar
  • 28 Lüke C, Lüke M, Dietlein T S. et al . Retinal tolerance to dyes.  Br J Ophthalmol. 2005;  89 1188-1191
    Search in Google Scholar
  • 29 Lüke C, Lüke M, Sickel W. et al . Effects of patent blue on human retinal function.  Graefe’s Arch Clin Exp Ophthalmol. 2006;  244 1188-1190
    Search in Google Scholar
  • 30 Maia M, Haller J A, Pieramici D J. et al . Retinal pigment epithelium abnormalities after internal limiting membrane peeling guided by indocyanine green staining.  Retina. 2004;  24 157-160
    Search in Google Scholar
  • 31 Maia M, Lenner L, deJuan E. et al . Effects of indocyanin green delivery over the retinal surface and into the subretinal space in rabbits.  Retina. 2004a;  24 80-91
    Search in Google Scholar
  • 32 Maia M, Margalit E, So M OM. et al . Effects of intravitreal indocyanin green injection in rabbits.  Retina. 2004b;  24 69-79
    Search in Google Scholar
  • 33 Maia M, Penha F, Rodrigues E B. et al . Effects of subretinal injection of patent blue and trypan blue in rabbits.  Curr Eye Res. 2007;  32 309-317
    Search in Google Scholar
  • 34 Mennel S, Meyer C H, Tietjen A. et al . Patent blue: a novel vital dye in vitreoretinal surgery.  Ophthalmologica. 2006;  220 190-193
    Search in Google Scholar
  • 35 Mennel S, Thumann G, Peter S. et al . Einfluss von Vitalfarbstoffen auf die Funktion der äußeren Blut-Retina-Schranke in vitro.  Klin Mbl Augenheilkd. 2006a;  223 568-576
    Search in Google Scholar
  • 36 Morrison V L, Koh H J, Cheng L. et al . Intravitreal toxicity of the kenalog vehicle (benzyl alcohol) in rabbits.  Retina. 2006;  26 339-344
    Search in Google Scholar
  • 37 Narayanan R, Kenney M C, Kamjoo S. et al . Trypan Blue: Effect of retinal pigment epithelial and neurosensory retinal cells.  Invest Ophthalmol Vis Sci. 2005;  46 304-309
    Search in Google Scholar
  • 38 Penha F, Maia M, Farah M E. et al . Effects of subretinal injections of indocyanine green, trypan blue, and glucose in rabbit eyes.  Ophthalmology. 2007;  114 899-908
    Search in Google Scholar
  • 39 Rodrigues E B, Meyer C H, Kroll P. Chromovitrectomy: a new field in vitreoretinal surgery.  Graefes Arch Clin Exp Ophthalmol. 2005;  243 291-293
    Search in Google Scholar
  • 40 Rodrigues E B, Meyer C H. Meta-analysis of chromovitrectomy with indocyanin green in macular hole surgery.  Ophthalmologica. 2008;  222 123-129
    Search in Google Scholar
  • 41 Ruiz-Moreno J M, Montero J A, Bayon A. et al . Retinal toxicity of intravitreal triamcinolone acetonide at high doses in the rabbit.  Exp Eye Res. 2007;  84 342-348
    Search in Google Scholar
  • 42 Schuettauf F, Haritoglou C, May C A. et al . Administration of novel dyes for intraocular surgery: an in vivo toxicity animal study.  Invest Ophthalmol Vis Sci. 2006;  47 3573-3578
    Search in Google Scholar
  • 43 Schumann R G, Remy M, Grueterich M. et al . How it appears: electron microscopic evaluation of internal limiting membrane specimens obtained during brilliant blue G assisted macular hole surgery.  Br J Ophthalmol. 2008;  92 330-331
    Search in Google Scholar
  • 44 Shah G K, Rosenblatt B J, Blinder K J. et al . Triamcinolone-assisted internal limiting membrane peeling.  Retina. 2005;  25 972-975
    Search in Google Scholar
  • 45 Sheidow T G, Blinder K J, Holekamp N. et al . Outcome results in macular hole surgery: an evaluation of internal limiting membrane peeling with and without indocyanine green.  Ophthalmology. 2003;  110 1697-1701
    Search in Google Scholar
  • 46 Slaughter K, Lee I L. Macular hole surgery with and without indocyanin green assistance.  Eye. 2004;  8 376-278
    Search in Google Scholar
  • 47 Teba F A, Mohr A, Eckhardt C. et al . Trypan blue staining in vitreoretinal surgery.  Ophthalmology. 2003;  110 2409-2412
    Search in Google Scholar
  • 48 Ueno A, Hisatomi T, Enaida H. et al . Biocompatibility of brilliant blue G in a rat model of subretinal injection.  Retina. 2007;  27 499-504
    Search in Google Scholar
  • 49 Uno F, Malerbi F, Maia M. et al . Subretinal trypan blue migration during epiretinal membrane peeling.  Retina. 2006;  26 237-239
    Search in Google Scholar
  • 50 Veckenmeer M, Overdam van K, Monzer J. et al . Ocular toxicity study of trypan blue injected into the vitreous cavity of rabbit eyes.  Graefes Arch Clin Exp Ophthalmol. 2001;  239 698-704
    Search in Google Scholar
  • 51 Vote B J, Russel M K, Joondeph B C. Trypan blue-assisted vitrectomy.  Retina. 2004;  24 736-738
    Search in Google Scholar

Prof. Dr. Heinrich Gerding, FEBO

Abteilung für Retinologie, Klinik Pallas

Louis-Giroud-Str. 20

4600 Olten

Schweiz