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DOI: 10.1055/s-0028-1119461
© Georg Thieme Verlag KG Stuttgart · New York
Malignes Melanom im Bestrahlungsfeld kurz nach Radiotherapie wegen Morbus Hodgkin
Malignant Melanoma Arising in a Radiotherapy Field Shortly After Radiation in a Patient with Morbus HodgkinPublikationsverlauf
Publikationsdatum:
05. März 2009 (online)

Zusammenfassung
Wir berichten über einen 30-jährigen Patienten, der vier Monate nach Strahlentherapie von mediastinalen Lymphomen bei Morbus Hodgkin (Stadium IV b) und vorausgegangener BACOPP-D (Bleomycin, Doxyrubicin, Cyclophosphamid, Vincristin, Procarbazin, Prednisolon und Dacarbazin)-Polychemotherapie im Bestrahlungsfeld ein malignes Melanom (Stadium I a) entwickelte. Daneben fanden sich Vitiligo-Herde und ein Halo-Nävus am sonstigen Integument. Der mögliche Zusammenhang zwischen der Entstehung eines malignen Melanoms und einer Strahlentherapie wird anhand der aktuellen Literatur diskutiert. Die regelmäßige Kontrolle des Bestrahlungsfeldes auf auffällige Hautveränderungen wird empfohlen.
Abstract
We report on a 30-years old male caucasian patient who developed a malignant melanoma (stage I a) in the radiotherapy field within four months after radiotherapy because of mediastinal lymphomas of Hodgkin's disease (stage IV b) and additional BACOPP-D (bleomycin, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisolone and dacarbazine) polychemotherapy in sequence. Beside of this, vitiligo lesions and a Sutton's nevus were present in other areas of the body. A possible causal connection between developement of melanoma and radiotherapy is discussed in the light of recent literature. The regular examination of radiation fields for skin changes is recommended.
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Prof. Dr. med. habil. Lutz Kowalzick
Klinik für Hautkrankheiten und Allergologie
HELIOS
Vogtland-Klinikum Plauen GmbH
Postfach 100153
08505 Plauen