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Planta Med 2009; 75(5): 541-543
DOI: 10.1055/s-0029-1185310
Natural Product Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Dammarane-Type Triterpene Glycosides from Oncoba manii Active against Methicillin-Resistant Staphylococcus aureus

Eliane Garo1 , Chia S. Hung1 , Russell B. Williams1 , Krista M. Olson1 , Jin-Feng Hu1 , Stephanie M. Rice1 , Grayson W. Hough1 , Matt G. Goering1 , Mark O'Neil-Johnson1 , Gary R. Eldridge1 , Courtney M. Starks1
  • 1Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., Saint Louis, Missouri, USA
Weitere Informationen

Publikationsverlauf

received August 25, 2008 revised November 17, 2008

accepted November 28, 2008

Publikationsdatum:
30. Januar 2009 (online)

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Abstract

Drug-resistant bacteria are becoming more prevalent both in the community and in hospitals. In a search for new antibiotic leads, we used a high-throughput natural products chemistry approach to isolate one new (1) and two known (2, 3) dammarane-type triterpenes with mass-limited material from the African plant Oncoba manii. The new compound was determined by spectroscopic methods to be 1β,2α,3β,20(R)-tetrahydroxydammar-24-ene 3-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside. Compounds 1 and 2 inhibited the growth of methicillin-resistant Staphylococcus aureus (MRSA).

Key words

Oncoba manii - Flacourtiaceae - dammarane - chilianoside - methicillin‐resistant Staphylococcus aureus

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Dr. Courtney Starks

Sequoia Sciences, Inc.

1912 Innerbelt Business Center Drive

St. Louis, MO 63114

USA

Telefon: + 1 31 43 73 51 81 ext. 1 07

Fax: + 1 31 43 73 51 86

eMail: cstarks@sequoiasciences.com