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DOI: 10.1055/s-0029-1185310
© Georg Thieme Verlag KG Stuttgart · New York
Dammarane-Type Triterpene Glycosides from Oncoba manii Active against Methicillin-Resistant Staphylococcus aureus
Publication History
received August 25, 2008
revised November 17, 2008
accepted November 28, 2008
Publication Date:
30 January 2009 (online)
Abstract
Drug-resistant bacteria are becoming more prevalent both in the community and in hospitals. In a search for new antibiotic leads, we used a high-throughput natural products chemistry approach to isolate one new (1) and two known (2, 3) dammarane-type triterpenes with mass-limited material from the African plant Oncoba manii. The new compound was determined by spectroscopic methods to be 1β,2α,3β,20(R)-tetrahydroxydammar-24-ene 3-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside. Compounds 1 and 2 inhibited the growth of methicillin-resistant Staphylococcus aureus (MRSA).
Key words
Oncoba manii - Flacourtiaceae - dammarane - chilianoside - methicillin‐resistant Staphylococcus aureus
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Dr. Courtney Starks
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