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DOI: 10.1055/s-0029-1185339
© Georg Thieme Verlag KG Stuttgart · New York
Effect of Triterpenoid Saponins from Bacopa monniera on Scopolamine-Induced Memory Impairment in Mice
Publication History
received October 20, 2008
revised Dec. 7, 2008
accepted Dec. 14, 2008
Publication Date:
12 February 2009 (online)
![](https://www.thieme-connect.de/media/plantamedica/200906/lookinside/thumbnails/10.1055-s-0029-1185339-1.jpg)
Abstract
Three new saponins, bacopasides IX−XI (1–3), together with their known analogues bacopaside I (4), bacopaside II (5), bacopasaponsin C (6), and bacopasaponsin D (7), were isolated from the whole plant of Bacopa monniera. Compounds 3, 4, and 6 showed nootropic activity when tested in the Morris water maze test and step-down test of scopolamine-induced memory impairment in mice.
Key words
Bacopa monniera (Linn.) Wettst. - Scrophulariaceae - saponin - nootropic activity - Morris water maze test - step‐down test
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Yun Zhou
Zhejiang Food and Drug Administration
No. 27 Wenbei Lane
Moganshan Road
Hangzhou 310012
Zhejiang Province
People's Republic of China
Phone: + 86 5 71 88 90 32 44
Fax: + 86 5 71 88 90 32 44
Email: yunzhoucn@yahoo.com.cn