Download PDF
Planta Med 2009; 75(6): 568-574
DOI: 10.1055/s-0029-1185339
Pharmacology
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Effect of Triterpenoid Saponins from Bacopa monniera on Scopolamine-Induced Memory Impairment in Mice

Yun Zhou1 , Ling Peng2 , Wei-Dong Zhang3 , De-Yun Kong4
  • 1Zhejiang Food and Drug Administration, Hangzhou, Zhejiang Province, P. R. China
  • 2Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, P. R. China
  • 3School of Pharmacy, Second Military Medical University, Shanghai, P. R. China
  • 4Shanghai Institute of Pharmaceutical Industry, Shanghai, P. R. China
Further Information

Publication History

received October 20, 2008 revised Dec. 7, 2008

accepted Dec. 14, 2008

Publication Date:
12 February 2009 (online)

Also available at
    Permissions and Reprints

Abstract

Three new saponins, bacopasides IX−XI (1–3), together with their known analogues bacopaside I (4), bacopaside II (5), bacopasaponsin C (6), and bacopasaponsin D (7), were isolated from the whole plant of Bacopa monniera. Compounds 3, 4, and 6 showed nootropic activity when tested in the Morris water maze test and step-down test of scopolamine-induced memory impairment in mice.

Key words

Bacopa monniera (Linn.) Wettst. - Scrophulariaceae - saponin - nootropic activity - Morris water maze test - step‐down test

References

  • 1 Mukherjee G D, Dey C D. Clinical trial on Brahmi. I.  J Exp Med Sci. 1966;  10 5-11
    PubMedGoogle Scholar
  • 2 Vohora D, Pal S N, Pillai K K. Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant.  J Ethnopharmacol. 2000;  71 383-390
    CrossrefPubMedGoogle Scholar
  • 3 Jain P, Khanna N K, Trehan N, Pendse V K, Godhwani J L. Antiinflammatory effects of an Ayurvedic preparation, Brahmi Rasayan, in rodents.  Indian J Exp Biol. 1994;  32 633-636
    PubMedGoogle Scholar
  • 4 Pawar R, Gopalakrishnan C, Bhutani K K. Dammarane triterpene saponin from Bacopa monniera as the superoxide inhibitor in polymorphonuclear cells.  Planta Med. 2001;  67 752-754
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Pawar R S, Khan S I, Khan I A. Glycosides of 20-deoxy derivatives of jujubogenin and pseudojujubogenin from Bacopa monniera.  Planta Med. 2007;  73 380-383
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Chatterjee N, Rastogi R P, Dhar M L. Chemical examination of Bacopa monniera Wetst. Part II: The constitution of bacoside A.  Indian J Chem. 1965;  3 24-28
    PubMedGoogle Scholar
  • 7 Rastogi S, Pal R, Kulshreshtha D K. Bacoside A3 – a triterpenoid saponin from Bacopa monniera.  Phytochemistry. 1994;  36 133-137
    CrossrefPubMedGoogle Scholar
  • 8 Garai S, Mahato S B, Ohtani K, Yamasaki K. Dammarane-type triterpenoid saponins from Bacopa monniera.  Phytochemistry. 1996;  42 815-820
    CrossrefPubMedGoogle Scholar
  • 9 Garai S, Mahato S B, Ohtani K, Yamasaki K. Bacopasaponin D – a pseudojujubogenin glycoside from Bacopa monniera.  Phytochemistry. 1996;  43 447-449
    CrossrefPubMedGoogle Scholar
  • 10 Zhou Y, Shen Y H, Zhang C, Zhang W D. Chemical constituents of Bacopa monnieri.  Chem Nat Compound. 2007;  43 355-357
    PubMedGoogle Scholar
  • 11 Zhou Y, Shen Y H, Zhang C, Su J, Liu R H, Zhang W D. Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models.  J Nat Prod. 2007;  70 652-655
    CrossrefPubMedGoogle Scholar
  • 12 Kim G S, Kim H T, Seong J D, Oh S R, Lee C O, Bang J K, Seong N S, Song K S. Cytotoxic steroidal saponins from the rhizomes of Asparagus oligoclonos.  J Nat Prod. 2005;  68 766-768
    CrossrefPubMedGoogle Scholar
  • 13 Morris R. Developments of a water-maze procedure for studying spatial learning in the rat.  J Neurosci Methods. 1984;  11 47-60
    CrossrefPubMedGoogle Scholar
  • 14 Mahato S B, Garai S, Chakravarty A K. Bacopasaponins E and F: two jujubogenin bisdesmosides from Bacopa monniera.  Phytochemistry. 2000;  53 711-714
    CrossrefPubMedGoogle Scholar
  • 15 Sara S J. Noradrenergic-cholinergic interaction: its possible role in memory dysfunction associated with senile dementia.  Arch Gerontol Geriatr Suppl. 1989;  1 99-108
    PubMedGoogle Scholar

Yun Zhou

Zhejiang Food and Drug Administration
No. 27 Wenbei Lane

Moganshan Road

Hangzhou 310012

Zhejiang Province

People's Republic of China

Phone: + 86 5 71 88 90 32 44

Fax: + 86 5 71 88 90 32 44

Email: yunzhoucn@yahoo.com.cn