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Planta Med 2009; 75(6): 568-574
DOI: 10.1055/s-0029-1185339
Pharmacology
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Effect of Triterpenoid Saponins from Bacopa monniera on Scopolamine-Induced Memory Impairment in Mice

Yun Zhou1 , Ling Peng2 , Wei-Dong Zhang3 , De-Yun Kong4
  • 1Zhejiang Food and Drug Administration, Hangzhou, Zhejiang Province, P. R. China
  • 2Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, P. R. China
  • 3School of Pharmacy, Second Military Medical University, Shanghai, P. R. China
  • 4Shanghai Institute of Pharmaceutical Industry, Shanghai, P. R. China
Weitere Informationen

Publikationsverlauf

received October 20, 2008 revised Dec. 7, 2008

accepted Dec. 14, 2008

Publikationsdatum:
12. Februar 2009 (online)

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Abstract

Three new saponins, bacopasides IX−XI (1–3), together with their known analogues bacopaside I (4), bacopaside II (5), bacopasaponsin C (6), and bacopasaponsin D (7), were isolated from the whole plant of Bacopa monniera. Compounds 3, 4, and 6 showed nootropic activity when tested in the Morris water maze test and step-down test of scopolamine-induced memory impairment in mice.

Key words

Bacopa monniera (Linn.) Wettst. - Scrophulariaceae - saponin - nootropic activity - Morris water maze test - step‐down test

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Yun Zhou

Zhejiang Food and Drug Administration
No. 27 Wenbei Lane

Moganshan Road

Hangzhou 310012

Zhejiang Province

People's Republic of China

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Fax: + 86 5 71 88 90 32 44

eMail: yunzhoucn@yahoo.com.cn