Effect of Triterpenoid Saponins from Bacopa monniera on Scopolamine-Induced Memory Impairment in Mice

Abstract

Three new saponins, bacopasides IX−XI (1–3), together with their known analogues bacopaside I (4), bacopaside II (5), bacopasaponsin C (6), and bacopasaponsin D (7), were isolated from the whole plant of Bacopa monniera. Compounds 3, 4, and 6 showed nootropic activity when tested in the Morris water maze test and step-down test of scopolamine-induced memory impairment in mice.

Key words

Bacopa monniera (Linn.) Wettst. - Scrophulariaceae - saponin - nootropic activity - Morris water maze test - step‐down test

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