A Peroxisome Proliferator-Activated Receptor-gamma Agonist and Other Constituents from Chromolaena odorata

Abstract

Peroxisome proliferator-activated receptors (PPARs) are key regulators of lipid and glucose metabolism and have become important therapeutic targets for various diseases. The phytochemical investigation of the chloroform-soluble extract of Chromolaena odorata led to the isolation of a PPAR-γ agonist, (9S,13R)-12-oxo-phytodienoic acid (1), together with 12 other compounds. The structures of chromomoric acid G (2), a new dehydrogenated derivative of 1, and chromolanone (3) were elucidated based on spectroscopic methods. Compound 1 showed a significant effect on PPAR-γ activation in comparison with rosiglitazone. However, compound 2 was inactive, suggesting that the dehydrogenation of the prostaglandin-like structure in 1 abrogates its PPAR-γ agonistic activity.

Key words

Chromolaena odorata - Asteraceae - (9S,13R)‐12‐oxo‐phytodienoic acid - chromomoric acid G - PPAR‐γ

References

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